中山醫學大學機構典藏 CSMUIR:Item 310902500/21070
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    题名: Therapeutic Efficacy Evaluation of Pegylated Liposome Encapsulated With Vinorelbine Plus 111 In Repeated Treatments in Human Colorectal Carcinoma With Multimodalities of Molecular Imaging
    作者: Yi-Chun Chien;Ying-Hsiang Chou;Wei-Hsun Wang;John Chun-Hao Chen;Wen-Shin Chang;Chia-Wen Tsai;DA-Tian Bau;Jeng-Jong Hwang
    贡献者: 醫學影像暨放射科學系暨碩士班
    关键词: Biodistribution;PEG-liposome;bioluminescence;colorectal cancer;micro positron emission tomography;pharmacokinetics.
    日期: 2020-01
    上传时间: 2020-08-10T12:51:02Z (UTC)
    出版者: CANCER GENOMICS & PROTEOMICS
    摘要: Abstract
    Background/aim: In precision therapy, liposomal encapsulated chemotherapeutic drugs have been developed to treat cancers by achieving higher drug accumulation in the tumor compared to normal tissues/organs.

    Materials and methods: We developed a novel chemoradiotherapeutic approach via nanoliposomes conjugated with vinorelbine (VNB) and 111In (111In-VNB-liposome) and examined their pharmacokinetics, biodistribution, maximum tolerance dose, and toxicity in a NOD/SCID mouse model.

    Results: Pharmacokinetic results showed that the area under the curve (AUC) of PEGylated liposomes was about 17-fold higher than that of the free radioisotope. Tumor growth inhibition by 111In-VNB-liposome was significantly higher than that of the control (p<0.05).

    Conclusion: The tumors in NOD/SCID mice bearing HT-29/tk-luc xenografts were significantly suppressed by 111In-VNB-liposomes. The study proposed repeated treatments with a novel liposome-mediated radiochemotherapy and validation of therapeutic efficacy via imaging.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21070
    關聯: CANCER GENOMICS & PROTEOMICS 17: 61-76 (2020)
    显示于类别:[醫學影像暨放射科學系暨碩士班] 期刊論文

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