中山醫學大學機構典藏 CSMUIR:Item 310902500/21034
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    题名: Reduced DAXX Expression Is Associated with Reduced CD24 Expression in Colorectal Cancer
    作者: Ya-Chun Chen;Tsung-Hsien Lee;Shu-Ling Tzeng
    贡献者: 醫學研究所
    关键词: colorectal cancer;DAXX;CD24;carcinoembryonic antigen;proliferation;metastasis
    日期: 2019-10-12
    上传时间: 2020-08-10T04:41:42Z (UTC)
    出版者: Cells
    摘要: Abstract
    The presence of an activating mutation of the Wnt/β-catenin signaling pathway is found in ~90% of colorectal cancer (CRC) cases. Death domain-associated protein (DAXX), a nuclear protein, interacts with β-catenin in CRC cells. We investigated DAXX expression in 106 matched sample pairs of CRC and adjacent normal tissue by Western blotting. This study evaluated DAXX expression and its clinical implications in CRC. The results revealed that DAXX expression was significantly lower in the patients with the positive serum carcinoembryonic antigen (CEA) screening results compared to the patients with negative CEA screening levels (p < 0.001). It has been reported that CD24 is a Wnt target in CRC cells. Here, we further revealed that DAXX expression was significantly correlated with CD24 expression (rho = 0.360, p < 0.001) in 106 patients. Consistent with this, in the CEA-positive subgroup, of which the carcinomas expressed DAXX at low levels, they were significantly correlated with CD24 expression (rho = 0.461, p < 0.005). Therefore, reduced DAXX expression is associated with reduced CD24 expression in CRC. Notably, in the Hct116 cells, DAXX knockdown using short-hairpin RNA against DAXX (shDAXX) not only caused significant cell proliferation, but also promoted metastasis. The DAXX-knockdown cells also demonstrated significantly decreased CD24 expression, however the intracellular localization of CD24 did not change. Thus, DAXX might be considered as a potential regulator of CD24 or β-catenin expression, which might be correlated with proliferative and metastatic potential of CRC.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21034
    關聯: Cells 2019, 8(10), 1242
    显示于类别:[醫學研究所] 期刊論文

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