Increased Type 2 Innate Lymphoid Cells in Patients with Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome

doi:10.1016/j.jid.2018.10.048

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/21021

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21021

Title:	Increased Type 2 Innate Lymphoid Cells in Patients with Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome
Authors:	Yi-Giien Tsai;Jia-Hung Liou;Shuen-Iu Hung;Chun-Bing Chen;Tsu-Man Chiu;Chuang-Wei Wang;Wen-Hung Chung
Contributors:	醫學系
Date:	2019-08
Issue Date:	2020-08-10T02:16:50Z (UTC)
Publisher:	Journal of Investigative Dermatology
Abstract:	Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening disorder with an estimated mortality rate of 2%. Recently, type II innate lymphoid cells (ILC2s) have been implicated as an important contributor to the pathogenesis of allergic disorders. However, the roles of ILC2s and ILC2- associated cytokines in DRESS remain unclear. Herein, we enrolled 54 participants (including 24 patients with DRESS syndrome and 30 healthy controls), and identified the increased ST2þILC2s population in skin lesions/blood. In addition, serum soluble ST2 (sST2), IL-5, and TSLP levels were significantly elevated at the acute stage of patients with DRESS. Decreased ILC2s population, serum sST2, and IL-5, accompanied with rash, eosinophilia, and alanine aminotransferase improvement were observed after steroid treatment. In the delayed-responders group (n ¼ 13), serum IL-33, sST2, IL-5, and TSLP levels were significantly increased at the acute phase, but only sST2 levels correlated with alanine aminotransferase and eosinophil improvement at the 4-week follow-up visit. Serum sST2 levels were also correlated with IL-33 (r ¼ 0.49; P ¼ 0.02) and alanine aminotransferase levels (r ¼ 0.65; P < 0.01) at the onset of DRESS. Our results demonstrated high IL-33/ST2 expression in ILC2 cells plays a role in skin inflammation of drug hypersensitivity, and serum sST2 levels can be as a potential biomarker to predict liver involvement in patients with DRESS syndrome.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/21021
Relation:	Journal of Investigative Dermatology Volume 139, Issue 8, August 2019, Pages 1722-1731
Appears in Collections:	[醫學系] 期刊論文

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