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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/21014
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| Title: | High agatston calcium score of intracranial carotid artery: A significant risk factor for cognitive impairment |
| Authors: | Kao, Hung-Wen
Liou, Michelle
Chung, Hsiao-Wen
Liu, Hua-Shan
Tsai, Ping-Huei
Chiang, Shih-Wei
Chou, Ming-Chung
Peng, Giia-Sheun
Huang, Guo-Shu
Hsu, Hsian-He
Chen, Cheng-Yu |
| Contributors: | 醫學影像暨放射科學系 |
| Date: | 2015-08-17 |
| Issue Date: | 2020-08-06T07:13:28Z (UTC)
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| Publisher: | Medicine (Baltimore) |
| ISSN: | 0025-7974 |
| Abstract: | Abstract: The effect of intracranial internal carotid artery (ICA)
calcification on cognitive impairment is uncertain. Our objective was
to investigate whether intracranial ICA calcification is a significant
cognitive predictor for cognitive impairment. Global cognition and
degrees of intracranial ICA calcification of 579 subjects were assessed
with Mini-Mental State Examination (MMSE) and Agatston calcium
scoring method, respectively. Other risk factors for cognitive impairment, including age, education level, hypertension, diabetes mellitus,
smoking, hyperlipidemia, and body mass index, were documented and
analyzed for their associations with cognitive function.
In univariate analyses, older age, lower education level, hypertension,
diabetes mellitus, and higher intracranial ICA Agatston scores were significantly associated with cognitive impairment. In ordinal logistic regression,
only age and total intracranial ICA Agatston score were significant risk
factors for cognitive impairment. After adjustment for the other documented
risk factors, subjects were 7% (95% CI: 5–10; P< 0.001) and 6% (95% CI:
0–13; P¼ 0.04) more likely to have lower cognitive category with every
year increment of age and every 100-point increment of the total intracranial
ICA Agatston score respectively. These results suggest an important role of
the intracranial ICA calcification on cognitive impairment. |
| URI: | https://ir.csmu.edu.tw:8080/ir/handle/310902500/21014 |
| Relation: | Medicine (Baltimore) . 2015 Sep;94(39):e1546. |
| Appears in Collections: | [醫學影像暨放射科學系暨碩士班] 期刊論文
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