中山醫學大學機構典藏 CSMUIR:Item 310902500/21012
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    题名: Abnormal perfusion in patellofemoral subchondral bone marrow in the rat anterior cruciate ligament transection model of post-traumatic osteoarthritis: a dynamic contrast-enhanced magnetic resonance imaging study
    作者: P.-H. Tsai;H.-S. Lee;T.Y. Siow;C.-Y. Wang;Y.-C. Chang;M.-H. Lin;Y.-C. Hsu;C.-H. Lee;H.-W. Chung;G.-S. Huang
    贡献者: 醫學影像暨放射科學系
    关键词: Post-traumatic osteoarthritisPatellofemoral jointAnterior cruciate ligamentDCE-MRIPerfusionSubchondral bone marrow
    日期: 2016-01-01
    上传时间: 2020-08-06T06:55:31Z (UTC)
    出版者: Osteoarthritis and Cartilage
    摘要: Summary
    Objective
    Although anterior cruciate ligament (ACL) injury is a well-recognized risk factor for developing knee post-traumatic osteoarthritis (PTOA), the process in the patellofemoral (PF) joint after ACL injury is still under-researched. Our aim was to investigate the perfusion changes in PF subchondral bone marrow in the rat ACL transection (ACLX) model of PTOA using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

    Design
    Eighteen male Sprague Dawley rats were randomly separated into three groups (n = 6 each group): a normal control group and groups receiving ACLX and sham-surgery, respectively, in the right knee. Perfusion parameters in the patellar and femoral subchondral bone marrows of all rats were measured on DCE-MRI at 0, 4, 8, and 16 weeks after respective treatment. After the last MRI at week 16, the rats were sacrificed and their right knees were harvested for histologic examination. In addition, to observe the long-term histologic change in PF joints, 9 additional rats (n = 3 in each group) were included and sacrificed at week 32 for histologic examination.

    Results
    In the ACLX group vs the sham and control groups, the perfusion parameters were significantly changed in both patellar and femoral subchondral bone marrows at week 16. Histologic examination revealed cartilage defects in ACLX rats at 32 weeks after surgery.

    Conclusions
    These data point to a possible functional relationship between subchondral bone marrow perfusion abnormalities and cartilage breakdown in PTOA. Moreover, the perfusion parameters derived from DCE-MRI can potentially serve as biomarkers of early OA.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/21012
    關聯: Osteoarthritis and Cartilage Volume 24, Issue 1, January 2016, Pages 129-133
    显示于类别:[醫學影像暨放射科學系暨碩士班] 期刊論文

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