| Abstract: | 目的：
本研究欲探討CDKAL1(CDK5 regulatory subunit associated protein 1-like 1)基因SNPs rs4712523及rs10946398對於臺灣族群罹患糖尿病的風險，以及不同飲食狀況的族群與rs4712523及rs10946398 SNPs對糖尿病的影響。
方法：
本研究採橫斷式研究，資料來源為臺灣人體生物資料庫(Taiwan Biobank, TWB)，依據CDKAL1基因SNPs進行分層，飲食習慣(宵夜習慣與外食習慣)作為自變項，糖尿病狀態分為無糖尿病、糖尿病前期與糖尿病，利用邏輯斯迴歸進行分析，其他納入考量的變項包含研究對象之性別、年齡、身體質量指數(BMI)、體脂肪率、吸菸行為與喝酒行為等因子。
結果：
研究對象共8782人，其中無糖尿病者4196人、糖尿病前期者3686人以及糖尿病者900人。透過多因子邏輯斯迴歸分析，在宵夜習慣方面，rs4712523與rs10946398基因型為AA的族群有宵夜習慣者，罹患糖尿病的風險皆較高(OR=1.86; 95%CI=1.37-2.52，OR=1.89; 95%CI=1.39-2.55)。在外食習慣方面，rs4712523基因型為GG的族群與rs10946398基因型為CC的族群有外食習慣者，罹患糖尿病前期的風險較高(OR=2.53; 95%CI=1.33-4.84，OR=2.59; 95%CI=1.34-4.99)。rs4712523基因型為GA的族群與rs10946398基因型為CA的族群有外食習慣者，罹患糖尿病的風險則較高(OR=1.98; 95%CI=1.10-3.57，OR=1.89; 95%CI=1.05-3.39)。宵夜習慣與外食習慣之交叉分層中，rs4712523基因型為AA的族群宵夜習慣與外食習慣皆有者，罹患糖尿病前期與糖尿病的風險皆較高(OR=1.53; 95%CI=1.04-2.26，OR=2.59; 95%CI=1.34-4.98)，rs4712523基因型為GA的族群宵夜習慣與外食習慣皆有者，罹患糖尿病的風險較高(OR=2.52; 95%CI=1.23-5.17)，然而，rs4712523基因型為GG的族群僅有宵夜習慣者罹患糖尿病的風險較高(OR=8.24; 95%CI=1.12-60.52)、宵夜習慣與外食習慣皆有者罹患糖尿病前期的風險則更高(OR=3.76; 95%CI=1.79-7.93)。另一方面，rs10946398基因型為AA的族群宵夜習慣與外食習慣皆有者，罹患糖尿病前期與糖尿病的風險皆較高(OR=1.53; 95%CI=1.05-2.23，OR=2.69; 95%CI=1.41-5.16)，rs10946398基因型為CA的族群宵夜習慣與外食習慣共有者，罹患糖尿病的風險也較高(OR=2.32; 95%CI=1.14-4.72)，並且rs10946398基因型CC族群宵夜習慣與外食習慣皆有者，罹患糖尿病前期的風險更較基因型為AA的族群為高(OR=3.85; 95%CI=1.79-8.29)。
結論：
本研究結果發現CDKAL1基因SNPs rs4712523與rs10946398和臺灣族群罹患糖尿病有顯著關聯；rs4712523基因型為GG的族群及rs10946398基因型為CC的族群，且宵夜習慣與外食習慣共有者，罹患糖尿病前期的風險較原生基因型AA為高；rs4712523基因型為AA或基因型為GA的族群，以及rs10946398基因型為AA或基因型為CA的族群，宵夜與外食習慣共有者，罹患糖尿病的風險也較高。
Objective:
This study aim to determine the associations between rs4712523 and rs10946398 SNPs on CDKAL1 (CDK5 regulatory subunit associated protein 1-like 1) and diabetes risk in Taiwanese population, as well as the impact of populations with different dietary habits and CDKAL1 gene rs4712523 and rs10946398 SNPs for diabetes.
Methods:
This study was conducted in a cross-sectional study. The data was obtained from Taiwan Biobank (TWB). The stratification was based on the CDKAL1 SNPs. Dietary habits (midnight snack, diner-out) were used as self-variation, and diabetes status was divided into diabetes, prediabetes and non-diabetes. Data was analyzed using logistic regression, and other variables considered included gender, age, body mass index (BMI), body fat ratio, smoking and drinking behavior.
Results:
8782 subjects were included in this study. 900 participants had diabetes, 3686 participants had prediabetes, and 4196 participants were non-diabetes. Using multiple logistic regression analysis, we investigated in rs4712523 and rs10946398, there is a significant risk of diabetes in subjects with AA genotype who had late night snack habit (OR=1.86; 95%CI=1.37-2.52，OR=1.89; 95%CI=1.39-2.55). Subjects with rs4712523 GG genotype and subjects with rs10946398 CC genotype who had eating outside habit conferred a higher risk of prediabetes (OR=2.53; 95%CI=1.33-4.84，OR=2.60; 95%CI=1.35-5.00). In addition, subjects with rs4712523 GA and rs10946398 CA genotype who had eating outside habit conferred a higher risk of diabetes (OR=1.98; 95%CI=1.10-3.57，OR=1.89; 95%CI=1.05-3.39). In the cross-stratification of late night snack habit and eating outside habit, Subjects with rs4712523 AA genotype who had both late night snack habit and eating outside habit, the risk of prediabetes and diabetes were higher (OR=1.53; 95%CI=1.04-2.26，OR=2.59; 95%CI=1.34-4.98). There is a significant risk of diabetes in subjects with rs4712523 GA genotype who had both two eating habits (OR=2.52; 95%CI=1.23-5.17). However, in GG genotype, there is a higher risk of diabetes in subjects who had just late night snack habit (OR=8.24; 95%CI=1.12-60.52). In the other hand, subjects who had both two eating habits are associated with a higher risk of pre-diabetes (OR=3.76; 95%CI=1.79-7.93). Subjects with rs10946398 AA genotype, found that both two eating habits had higher risk of prediabetes and diabetes (OR=1.53; 95%CI=1.05-2.23，OR=2.69; 95%CI=1.41-5.16). Subjects with rs10946398 CA genotype who had both two eating habits conferred a higher risk of diabetes (OR=2.32; 95%CI=1.14-4.72). However, in the rs10946398 CC genotype, both two eating habits had higher risk of pre-diabetes than AA (OR=3.85; 95%CI=1.79-8.29).
Conclusions:
We found that CDKAL1 gene SNPs rs4712523 and rs10946398 and Taiwan population have significant association with diabetes. Population with rs4712523 GG genotype, or rs10946398 CC genotype, and there is a combination of late night snack habit and eating outside habits, had higher risk of pre-diabetes than the original genotype AA. Moreover, Individuals with rs4712523 AA/GA genotypes, or rs10946398 AA/CA genotypes, and there is a combination of late night snack habit and eating outside habits, had higher risk of diabetes. |
