Clinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase

doi:10.1016/j.pnpbp.2020.109868

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/20651

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/20651

Title:	Clinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase
Authors:	Chien, Y.-L. Hwu, H.-G. Hwang, T.-J. Hsieh, M.H. Liu, C.-C. Lin-Shiau, S.-Y. Liu, C.-M.
Keywords:	Lipid peroxidation;Nitric oxide;Oxidative stress;Schizophrenia;Superoxide dismutase;Symptoms
Date:	2020-04
Issue Date:	2020-03-25T04:20:33Z (UTC)
Publisher:	Progress in Neuro-Psychopharmacology and Biological Psychiatry
ISSN:	0278-5846
Abstract:	Several studies have suggested a higher oxidative stress in schizophrenia. However, the implications of oxidative stress on clinical symptoms remain unclear. This study aimed to investigate the platelet oxidative stress in different stages of schizophrenia (i.e., chronic stable and acute relapse) in order to clarify the clinical implications of oxidative stress and the treatment effects. We recruited 43 chronic stable patients with schizophrenia and 48 non-psychiatric controls. Platelets were collected for measuring the levels of nitric oxide (NO), lipid peroxidation (LPO), and glutathione (GSH) and the activity of GSH peroxidase (GPx) and superoxide dismutase (SOD). The levels and activity were compared between patients and controls and were examined for their relationship with clinical severity. Further, we evaluated the changes of levels and activity before and after treatment in an independent sample with acute relapse (N = 19). Patients with chronic stable schizophrenia had lower SOD activity compared to non-psychiatric controls. In chronic stable patients, NO level was positively correlated with positive and disorganized symptoms, while the GPx activity were negatively correlated with excitement. In patients with acute relapse, the levels and activity were not different before and after four weeks of antipsychotic treatment, but LPO level was negatively correlated with pretreatment disorganized symptoms. The change of LPO can also predict the change of disorganized symptoms and negative symptoms. Our findings suggest that platelet SOD was lower in chronic stable schizophrenia. Platelet LPO may be associated with less disorganized symptoms in acute relapse patients and better treatment response. © 2020
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/20651
Relation:	Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 99, no.109868
Appears in Collections:	[口腔醫學研究所] 期刊論文

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