Enterotype-based Analysis of Gut Microbiota along the Conventional Adenoma-Carcinoma Colorectal Cancer Pathway

doi:10.1038/s41598-019-45588-z

中山醫學大學機構典藏 CSMUIR > 附設醫院 > 期刊論文 > Item 310902500/20455

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题名:	Enterotype-based Analysis of Gut Microbiota along the Conventional Adenoma-Carcinoma Colorectal Cancer Pathway
作者:	Yang, T.-W. Lee, W.-H. Tu, S.-J. Huang, W.-C. Chen, H.-M. Sun, T.-H. Tsai, M.-C. Wang, C.-C. Chen, H.-Y. Huang, C.-C. Shiu, B.-H. Yang, T.-L. Huang, H.-T. Chou, Y.-P. Chou, C.-H. Huang, Y.-R. Sun, Y.-R. Liang, C. Lin, F.-M. Ho, S.-Y. Chen, W.-L. Yang, S.-F.
关键词:	Metagenome;Colorectal Neoplasms;Colorectal carcinogenesis
日期:	2019-12
上传时间:	2019-11-14T09:24:32Z (UTC)
ISSN:	20452322
摘要:	The dysbiosis of human gut microbiota is strongly associated with the development of colorectal cancer (CRC). The dysbiotic features of the transition from advanced polyp to early-stage CRC are largely unknown. We performed a 16S rRNA gene sequencing and enterotype-based gut microbiota analysis study. In addition to Bacteroides- and Prevotella-dominated enterotypes, we identified an Escherichia-dominated enterotype. We found that the dysbiotic features of CRC were dissimilar in overall samples and especially Escherichia-dominated enterotype. Besides a higher abundance of Fusobacterium, Enterococcus, and Aeromonas in all CRC faecal microbiota, we found that the most notable characteristic of CRC faecal microbiota was a decreased abundance of potential beneficial butyrate-producing bacteria. Notably, Oscillospira was depleted in the transition from advanced adenoma to stage 0 CRC, whereas Haemophilus was depleted in the transition from stage 0 to early-stage CRC. We further identified 7 different CAGs by analysing bacterial clusters. The abundance of microbiota in cluster 3 significantly increased in the CRC group, whereas that of cluster 5 decreased. The abundance of both cluster 5 and cluster 7 decreased in the Escherichia-dominated enterotype of the CRC group. We present the first enterotype-based faecal microbiota analysis. The gut microbiota of colorectal neoplasms can be influenced by its enterotype. © 2019, The Author(s).
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/20455
關聯:	Scientific Reports, Volume 9, Issue 1, 1 December 2019, NO.10923
显示于类别:	[附設醫院] 期刊論文

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