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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/20455
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| Title: | Enterotype-based Analysis of Gut Microbiota along the Conventional Adenoma-Carcinoma Colorectal Cancer Pathway |
| Authors: | Yang, T.-W.
Lee, W.-H.
Tu, S.-J.
Huang, W.-C.
Chen, H.-M.
Sun, T.-H.
Tsai, M.-C.
Wang, C.-C.
Chen, H.-Y.
Huang, C.-C.
Shiu, B.-H.
Yang, T.-L.
Huang, H.-T.
Chou, Y.-P.
Chou, C.-H.
Huang, Y.-R.
Sun, Y.-R.
Liang, C.
Lin, F.-M.
Ho, S.-Y.
Chen, W.-L.
Yang, S.-F. |
| Keywords: | Metagenome;Colorectal Neoplasms;Colorectal carcinogenesis |
| Date: | 2019-12 |
| Issue Date: | 2019-11-14T09:24:32Z (UTC)
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| ISSN: | 20452322 |
| Abstract: | The dysbiosis of human gut microbiota is strongly associated with the development of colorectal cancer (CRC). The dysbiotic features of the transition from advanced polyp to early-stage CRC are largely unknown. We performed a 16S rRNA gene sequencing and enterotype-based gut microbiota analysis study. In addition to Bacteroides- and Prevotella-dominated enterotypes, we identified an Escherichia-dominated enterotype. We found that the dysbiotic features of CRC were dissimilar in overall samples and especially Escherichia-dominated enterotype. Besides a higher abundance of Fusobacterium, Enterococcus, and Aeromonas in all CRC faecal microbiota, we found that the most notable characteristic of CRC faecal microbiota was a decreased abundance of potential beneficial butyrate-producing bacteria. Notably, Oscillospira was depleted in the transition from advanced adenoma to stage 0 CRC, whereas Haemophilus was depleted in the transition from stage 0 to early-stage CRC. We further identified 7 different CAGs by analysing bacterial clusters. The abundance of microbiota in cluster 3 significantly increased in the CRC group, whereas that of cluster 5 decreased. The abundance of both cluster 5 and cluster 7 decreased in the Escherichia-dominated enterotype of the CRC group. We present the first enterotype-based faecal microbiota analysis. The gut microbiota of colorectal neoplasms can be influenced by its enterotype. © 2019, The Author(s). |
| URI: | https://ir.csmu.edu.tw:8080/ir/handle/310902500/20455 |
| Relation: | Scientific Reports, Volume 9, Issue 1, 1 December 2019, NO.10923 |
| Appears in Collections: | [附設醫院] 期刊論文
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| Enterotypebased-Analysis-of-Gut-Microbiota-along-the-Conventional-AdenomaCarcinoma-Colorectal-Cancer-Pathway2019Scientific-Reports.pdf | | 3191Kb | Adobe PDF | 188 | View/Open |
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