Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-κB Pathway

doi:10.1038/s41598-019-49486-2

中山醫學大學機構典藏 CSMUIR > 附設醫院 > 期刊論文 > Item 310902500/20454

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/20454

Title:	Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-κB Pathway
Authors:	Chuang, H.-Y. Lee, Y.-P. Lin, W.-C. Lin, Y.-H. Hwang, J.-J.
Keywords:	Fatty Acid Synthetase Complex;Neoplasms;Acid synthase
Date:	2019-12
Issue Date:	2019-11-14T09:20:02Z (UTC)
ISSN:	2045-2322
Abstract:	Elevated fatty acid synthase (FASN) has been reported in both androgen-dependent and -independent prostate cancers. Conventional treatment for prostate cancer is radiotherapy (RT); however, the following radiation-induced radioresistance often causes treatment failure. Upstream proteins of FASN such as Akt and NF-κB are found increased in the radioresistant prostate cancer cells. Nevertheless, whether inhibition of FASN could improve RT outcomes and reverse radiosensitivity of prostate cancer cells is still unknown. Here, we hypothesised that orlistat, a FASN inhibitor, could improve RT outcomes in prostate cancer. Orlistat treatment significantly reduced the S phase population in both androgen-dependent and -independent prostate cancer cells. Combination of orlistat and RT significantly decreased NF-κB activity and related downstream proteins in both prostate cancer cells. Combination effect of orlistat and RT was further investigated in both LNCaP and PC3 tumour-bearing mice. Combination treatment showed the best tumour inhibition compared to that of orlistat alone or RT alone. These results suggest that prostate cancer treated by conventional RT could be improved by orlistat via inhibition of FASN. © 2019, The Author(s).
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/20454
Relation:	Scientific Reports, Volume 9, Issue 1, 1 December 2019, NO.13284
Appears in Collections:	[附設醫院] 期刊論文

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