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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/20453
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| Title: | Flunarizine related movement disorders: a nationwide population-based study |
| Authors: | Jhang, K.-M.
Huang, J.-Y.
Nfor, O.N.
Tung, Y.-C.
Ku, W.-Y.
Jan, C.-F.
Liaw, Y.-P. |
| Keywords: | Parkinsonian Disorders;Pharmaceutical Preparations;Drug-induced parkinsonism |
| Date: | 2019-12 |
| Issue Date: | 2019-11-14T09:14:38Z (UTC)
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| ISSN: | 2045-2322 |
| Abstract: | Flunarizine (fz) causes side effects such as movement disorders (MDs). We investigated risk factors associated with fz-related MDs. Participants were recruited from the longitudinal health insurance databases and included patients who took fz for more than 1 month. Patients with one of the underlying diseases, or with concomitant drug use (antipsychotics, metoclopramide or reserpine), and those diagnosed with MDs before fz use were excluded. Fz-related MD was defined as a new diagnosis of parkinsonism or hyperkinetic syndrome including dyskinesia or secondary dystonia during fz use or within 3 months after drug discontinuation. After exposure, 288 individuals had fz-related MDs (parkinsonism, n = 240; hyperkinesia, n = 48). Risk factors associated with these disorders were higher-dose exposure (cumulative defined daily dose [cDDD] ≥87.75, odds ratio [OR]: 3.80; 95% CI: 2.61–5.52), older age (OR: 1.07; 95% CI: 1.06–1.09), history of essential tremor (OR: 6.39; 95% CI: 2.29–17.78) and cardiovascular disease (CVD) (OR: 1.47; 95% CI: 1.14–1.9). The optimal value of cDDD to predict MDs was 58.5 (sensitivity: 0.67, specificity: 0.60), indicating an overall exposure of 585 mg. Higher exposure dose and duration, older age, history of essential tremor, and CVD were associated with fz-associated MDs. Clinicians ought to watch for extrapyramidal side effects when prescribing fz. © 2019, The Author(s). |
| URI: | https://ir.csmu.edu.tw:8080/ir/handle/310902500/20453 |
| Relation: | Scientific Reports, Volume 9, Issue 1, 1 December 2019, NO.1705 |
| Appears in Collections: | [附設醫院] 期刊論文
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| Flunarizine-related-movement-disorders-a-nationwide-populationbased-study2019Scientific-Reports.pdf | | 953Kb | Adobe PDF | 175 | View/Open |
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