Diagnostic performance of serum interleukin-6 and interleukin-10 levels and clinical predictors in children with rotavirus and norovirus gastroenteritis

doi:10.1016/j.cyto.2012.04.034

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/20403

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题名:	Diagnostic performance of serum interleukin-6 and interleukin-10 levels and clinical predictors in children with rotavirus and norovirus gastroenteritis
作者:	Chen, Shan-Ming Ku, Min-Sho Lee, Ming-Yung Tsai, Jeng-Dau Sheu, Ji-Nan
贡献者:	醫學系
关键词:	Interleukin-6;Interleukin-10;Norovirus;Rotavirus
日期:	2012-08
上传时间:	2019-10-24T03:38:13Z (UTC)
出版者:	Cytokine
ISSN:	1043-4666
摘要:	Objectives Rotavirus and norovirus are the two most common causes of acute viral gastroenteritis in children. This study aimed to explore the association of serum interleukin-6 (IL-6) and interleukin-10 (IL-10) levels and the clinical features in children with rotavirus and norovirus gastroenteritis. Methods This prospective study enrolled 168 acute gastroenteritis patients admitted to a tertiary care center. Peripheral blood samples were collected for IL-6 and IL-10 assays within the first 72 h of illness. The diagnostic performance of clinical tests was estimated using the receiver operating characteristic (ROC) analysis. Binary logistic regression modeling was performed to examine the predictive variables. Results Serum IL-6 and IL-10 were measured in children with rotavirus infection (n = 30), norovirus infection (n = 25), Salmonella infection (n = 26), and in 11 healthy controls. There were significant higher degrees of severity of illness and levels of IL-10 in the rotavirus group as compared to the norovirus group. The binary logistic regression analysis revealed that both the ANC and maximum body temperature (BT) were significant clinical predictors for discriminating rotavirus and norovirus gastroenteritis. The ROC curve to evaluate the accuracy of logistic regression model had an AUC of 0.847 (95% CI: 0.741–0.952, p < 0.001). Conclusions IL-10 shows a significant discriminating ability between rotavirus and norovirus infection. A model incorporating maximum BT and ANC can help pediatricians to distinguish between rotavirus and norovirus in children with a suspected viral gastroenteritis.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/20403
關聯:	Cytokine, Volume 59, Issue 2, 299-304
显示于类别:	[醫學系] 期刊論文

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