A subacute toxicity evaluation of green tea (Camellia sinensis) extract in mice

doi:10.1016/j.fct.2011.07.007

中山醫學大學機構典藏 CSMUIR > 健康管理學院 > 職業安全衛生學系暨碩士班 > 期刊論文 > Item 310902500/20320

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/20320

Title:	A subacute toxicity evaluation of green tea (Camellia sinensis) extract in mice
Authors:	Hsu, Yu-Wen Tsai, Chia-Fang Chen, Wen-Kang Huang, Chun-Fa Yen, Cheng-Chieh
Keywords:	Catechins;Green tea extract;Mice;Subacute toxicity
Date:	2011-10
Issue Date:	2019-08-15T08:49:06Z (UTC)
Publisher:	Food and Chemical Toxicology
ISSN:	0278-6915
Abstract:	Green tea is believed to be beneficial to health because it possesses antioxidant, antiviral and anticancer properties. The potential toxicity of green tea when administered at high doses via concentrated extracts, however, has not been completely investigated. The objective of the present study was to evaluate the safety of green tea extract in ICR mice using a subacute exposure paradigm. In this study, mice were orally administered (gavage) green tea extract at doses of 0 (as normal group), 625, 1250 and 2500 mg/kg body weight/day for 28 days. The results showed that oral administration of green tea extract did not cause adverse effects on body weight, organ weights, hematology, serum biochemistry, urinalysis or histopathology. Additionally, administering green tea extract via gavage significantly reduced triglyceride and cholesterol levels. These observed effects could be attributed to the high levels of catechins present in green tea as these compounds have been reported to have beneficial health effects. The no-observed-adverse-effect level for green tea extract derived from the results of the present study was 2500 mg/kg body weight/day.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/20320
Relation:	Food and Chemical Toxicology, Volume 49, Issue 10, 2624-2630
Appears in Collections:	[職業安全衛生學系暨碩士班] 期刊論文

Files in This Item:

File	Description	Size	Format
1-s2.0-S0278691511003309-main.pdf		209Kb	Adobe PDF	262	View/Open

View Licence

Loading...