Mercuric Compounds Induce Pancreatic Islets Dysfunction and Apoptosis in Vivo

doi:10.3390/ijms131012349

中山醫學大學機構典藏 CSMUIR > 健康管理學院 > 職業安全衛生學系暨碩士班 > 期刊論文 > Item 310902500/20318

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题名:	Mercuric Compounds Induce Pancreatic Islets Dysfunction and Apoptosis in Vivo
作者:	Chen, Kuo-Liang;Liu, Shing-Hwa;Su, Chin-Chuan;Yen, Cheng-Chieh;Yang, Ching-Yao;Lee, Kuan-I;Tang, Feng-Cheng;Chen, Ya-Wen;Lu, Tien-Hui;Su, Yi-Chang;Huang, Chun-Fa
关键词:	mercuric compounds;pancreatic islets;oxidative stress;apoptosis
日期:	2012-10
上传时间:	2019-08-15T08:36:40Z (UTC)
出版者:	International journal of molecular sciences
ISSN:	1422-0067
摘要:	Mercury is a toxic heavy metal that is an environmental and industrial pollutant throughout the world. Mercury exposure leads to many physiopathological injuries in mammals. However, the precise toxicological effects of mercury on pancreatic islets in vivo are still unclear. Here, we investigated whether mercuric compounds can induce dysfunction and damage in the pancreatic islets of mice, as well as the possible mechanisms involved in this process. Mice were treated with methyl mercuric chloride (MeHgCl, 2 mg/kg) and mercuric chloride (HgCl2, 5 mg/kg) for more than 2 consecutive weeks. Our results showed that the blood glucose levels increased and plasma insulin secretions decreased in the mice as a consequence of their exposure. A significant number of TUNEL-positive cells were revealed in the islets of mice that were treated with mercury for 2 consecutive weeks, which was accompanied by changes in the expression of the mRNA of anti-apoptotic (Bcl-2, Mcl-1, and Mdm-2) and apoptotic (p53, caspase-3, and caspase-7) genes. Moreover, plasma malondialdehyde (MDA) levels increased significantly in the mice after treatment with mercuric compounds for 2 consecutive weeks, and the generation of reactive oxygen species (ROS) in the pancreatic islets also markedly increased. In addition, the mRNA expression of genes related to antioxidation, including Nrf2, GPx, and NQO1, were also significantly reduced in these islets. These results indicate that oxidative stress injuries that are induced by mercuric compounds can cause pancreatic islets dysfunction and apoptosis in vivo.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/20318
關聯:	International journal of molecular sciences, vol. 13, issue 10, 12349-12366
显示于类别:	[職業安全衛生學系暨碩士班] 期刊論文

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