Resveratrol Enhances Chemosensitivity in Mouse Melanoma Model Through Connexin 43 Upregulation

doi:10.1002/tox.21952

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 生物醫學科學學系暨碩士班 > 期刊論文 > Item 310902500/20275

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/20275

Title:	Resveratrol Enhances Chemosensitivity in Mouse Melanoma Model Through Connexin 43 Upregulation
Authors:	Cheng, Yu‐Jung;Chang, Meng‐Ya;Chang, Wen‐Wei;Wang, Wei‐Kuang;Liu, Chi‐Fan;Lin, Song‐Tao;Lee, Che‐Hsin
Keywords:	gap junctions;connexin 43;resveratrol;cisplatin
Date:	2014-01
Issue Date:	2019-07-17T08:06:19Z (UTC)
Publisher:	Environmental Toxicology
ISSN:	1520-4081
Abstract:	Although current studies indicate that resveratrol exhibits potential antitumor activities, the precise mechanisms of its beneficial effects combined with chemotherapy are not fully understood. This work is warranted to elucidate the underlying mechanism of antitumor effects by the combination therapy of resveratrol and cisplatin. The presence of functional gap junctions is highly relevant for the success of chemotherapy. Gap junctions mediate cell communication by allowing the passage of molecules from one cell to another. Connexin (Cx) 43 is ubiquitous and reduced in a variety of tumor cells. Cx43 may influence the response of tumor cells to treatments by facilitating the passage of antitumor drugs or death signals between neighboring tumor cells. Following resveratrol treatment, dose‐dependent upregulation of Cx43 expressions was observed. In addition, gap junction intercellular communication was increased. To study the mechanism underlying these resveratrol‐induced Cx43 expressions, we found that resveratrol induced a significant increase in mitogen‐activated protein kinases (MAPK) signaling pathways. The MAPK inhibitors significantly reduced the expression of Cx43 protein after resveratrol treatment. Specific knockdown of Cx43 resulted in a reduction of cell death after resveratrol and cisplatin treatment. Our results suggest that treatment of resveratrol in tumor leads to increase Cx43 gap junction communication and enhances the combination of resveratrol and cisplatin therapeutic effects. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 877–886, 2015.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/20275
Relation:	Environmental Toxicology, vol. 30, issue 8, 877-886
Appears in Collections:	[生物醫學科學學系暨碩士班] 期刊論文

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