中山醫學大學機構典藏 CSMUIR:Item 310902500/20268
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    题名: An Extract of Rhodobacter sphaeroides Reduces Cisplatin-Induced Nephrotoxicity in Mice
    作者: Chang, Wen-Wei
    Liu, Jau-Jin
    Liu, Chi-Fan
    Liu, Wen-Sheng
    Lim, Yun-Ping
    Cheng, Yu-Jung
    Lee, Che-Hsin
    关键词: Rhodobacter sphaeroides;Lycogen™;cisplatin;nephrotoxicity
    日期: 2013-12
    上传时间: 2019-07-17T07:19:40Z (UTC)
    出版者: Toxins
    ISSN: 2072-6651
    摘要: Cisplatin is used as a treatment for various types of solid tumors. Renal injury severely limits the use of cisplatin. Renal cell apoptosis, oxidative stress, and inflammation contribute to cisplatin-induced nephrotoxicity. Previously, we found that an extract of Rhodobacter sphaeroides (Lycogen™) inhibited proinflammatory cytokines and the production of nitric oxide in activated macrophages in a dextran sodium sulfate (DSS)-induced colitis model. Here, we evaluated the effect of Lycogen™, a potent anti-inflammatory agent, in mice with cisplatin-induced renal injury. We found that attenuated renal injury correlated with decreased apoptosis due to a reduction in caspase-3 expression in renal cells. Oral administration of Lycogen™ significantly reduced the expression of tumor necrosis factor-α and interleukin-1β in mice with renal injury. Lycogen™ reduces renal dysfunction in mice with cisplatin-induced renal injury. The protective effects of the treatment included blockage of the cisplatin-induced elevation in serum urea nitrogen and creatinine. Meanwhile, Lycogen™ attenuated body weight loss and significantly prolonged the survival of mice with renal injury. We propose that Lycogen™ exerts anti-inflammatory activities that represent a promising strategy for the treatment of cisplatin-induced renal injury.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/20268
    關聯: Toxins (Basel), vol. 5, issue 12, 2353–2365.
    显示于类别:[生物醫學科學學系暨碩士班] 期刊論文

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