Lipid‐Lowering Effects of Curcumin in Patients with Metabolic Syndrome: A Randomized, Double‐Blind, Placebo‐Controlled Trial

doi:10.1002/ptr.5197

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/20226

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/20226

Title:	Lipid‐Lowering Effects of Curcumin in Patients with Metabolic Syndrome: A Randomized, Double‐Blind, Placebo‐Controlled Trial
Authors:	Yang, Yi‐Sun Su, Ying‐Fang Yang, Hui‐Wen Lee, Yu‐Hsien Chou, Janet I. Ueng, Kwo‐Chang
Contributors:	中山醫學大學口腔醫學研究所
Keywords:	curcumin;lipid‐lowering effect;metabolic syndrome
Date:	2014-08
Issue Date:	2019-06-14T03:25:55Z (UTC)
Publisher:	Phytotherapy Research
ISSN:	0951-418X
Abstract:	Human studies of curcumin extract on lipid‐lowering effect have not been completely investigated and have had controversy results. This study tested the effect of daily curcumin extract for 12 weeks on weight, glucose, and lipid profiles in patients with metabolic syndrome. Sixty‐five patients were randomized into two groups; 33 patients taking curcumin extract capsule (630 mg thrice daily) and 32 patients taking a placebo capsule thrice daily for 12 weeks. At 12 weeks after the curcumin extract consumption, the level of high‐density lipoprotein cholesterol (HDL‐C) significantly increased from 40.96 ± 8.59 to 43.76 ± 2.79 mg/dL (p < 0.05), and the level of low‐density lipoprotein cholesterol (LDL) was significantly reduced (120.55 ± 36.81 to 106.51 ± 25.02 mg/dL, p < 0.05). The triglyceride‐lowering effect, a reduction of 65 mg/dL, was also found in this study. In subgroups analysis, the consumption of curcumin may have a lowering cholesterol effect in male patients and an increasing HDL‐C effect in female patients, both of which result in a decrease of T‐Chol/HDL‐C ratio. The intake of the curcumin extract of 1890 mg/day for 12 weeks was associated with lipid‐lowering effect but did not improve weight and glucose homeostasis in the patients with metabolic syndrome. Daily curcumin consumption may be an alternative choice to modify cholesterol‐related parameters, especially in metabolic syndrome patients. Copyright © 2014 John Wiley & Sons, Ltd.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/20226
Relation:	Phytotherapy Research, Vol. 28, Issue12, 1770-1777
Appears in Collections:	[口腔醫學研究所] 期刊論文

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