Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activation

doi:10.18632/oncotarget.13755

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/20217

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题名:	Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activation
作者:	Yang, Po-Yu Hsieh, Pei-Ling Wang, Tong Hong Yu, Cheng-Chia Lu, Ming-Yi Liao, Yi-Wen Lee, Tzu-Hsin Peng, Chih-Yu
贡献者:	中山醫學大學口腔醫學院
关键词:	oral squamous cell carcinomas;andrographolide;miR-218;cancer stemness
日期:	2017-01
上传时间:	2019-06-04T03:32:49Z (UTC)
出版者:	Oncotarget
ISSN:	1949-2553
摘要:	Current evidence suggests that oral cancer stem cells (OCSCs) possess high tumorigenic and metastatic properties as well as chemo- and radioresistance. In this study, we demonstrated that andrographolide, the main bioactive component in the medicinal plant Andrographis, significantly reduced oncogenicity and restored radio-sensitivity of ALDH1+CD44+ OCSCs. Mechanistic studies showed that andrographolide treatment increased the expression of microRNA-218 (miR-218), leading to the downregulation of Bmi1. We showed that knockdown of miR-218 in ALDH1−CD44− non-OCSCs enhanced cancer stemness, while silencing of Bmi1 significantly counteracted it. Furthermore, we found tumor growth was reduced in mice bearing xenograft tumors after andrographolide treatment via activation of miR-218/Bmi1 axis. Together, these data demonstrated that the inhibition of tumor aggressiveness in OCSCs by andrographolide was mediated through the upregulation of miR-218, thereby reducing Bmi1 expression. These findings suggest that andrographolide may be a valuable natural compound for anti-CSCs treatment of OSCC.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/20217
關聯:	Oncotarget. 2017 Jan 17; 8(3): 4196–4207.
显示于类别:	[口腔醫學研究所] 期刊論文

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