中山醫學大學機構典藏 CSMUIR:Item 310902500/20207
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    题名: Malignant transformation of oral submucous fibrosis in Taiwan: A nationwide population‐based retrospective cohort study
    作者: Yang, Po‐Yu
    Chen, Yi‐Tzu
    Wang, Yu‐Hsun
    Su, Ni‐Yu
    Yu, Hui‐Chieh
    Chang, Yu‐Chao
    贡献者: 中山醫學大學
    关键词: cohort study;malignant transformation;nationwide population;oral submucous fibrosis
    日期: 2017-03
    上传时间: 2019-05-31T03:54:29Z (UTC)
    出版者: Wiley Online Library
    ISSN: 1600-0714
    摘要: Background
    Oral submucous fibrosis (OSF) is one of the well‐recognized oral potentially malignant disorders. In this study, we investigated the malignant transformation of OSF in a Taiwanese population.

    Methods
    A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. A comparison cohort was randomly frequency‐matched with the OSF cohort according to age, sex, and index year. Oral leukoplakia (OL) was further stratified to evaluate for the possible synergistic effects of OSF‐associated malignant transformation.

    Results
    In this cohort, 71 (9.13%) of 778 cases of OSF were observed to transform into oral cancer. The malignant transformation rate was 29.26‐fold in the OSF cohort than in the comparison cohort after adjustment (95% confidence intervals 20.55‐41.67). To further stratify with OL, OSF with OL (52.46%; 95% confidence intervals 34.88‐78.91) had higher risk of malignant transformation rate than OSF alone (29.84%; 95% confidence intervals 20.99‐42.42). The Kaplan‐Meier plot revealed the rate free of malignant transformation was significant over the 13‐year follow‐up period (log‐rank test, P<.001). The mean duration of malignant transformation was 5.1, 2.7, and 2.2 years for non‐OSF, OSF alone, and OSF with OL, respectively.

    Conclusion
    Oral submucous fibrosis patients exhibited a significantly higher risk of malignant transformation than those without OSF. OL could enhance malignant transformation in patients with OSF.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/20207
    關聯: Journal of Oral Pathology & Medicine, vol.16, issue 10, 1040-1045
    显示于类别:[口腔醫學研究所] 期刊論文

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