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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/20207
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| Title: | Malignant transformation of oral submucous fibrosis in Taiwan: A nationwide population‐based retrospective cohort study |
| Authors: | Yang, Po‐Yu
Chen, Yi‐Tzu
Wang, Yu‐Hsun
Su, Ni‐Yu
Yu, Hui‐Chieh
Chang, Yu‐Chao |
| Contributors: | 中山醫學大學 |
| Keywords: | cohort study;malignant transformation;nationwide population;oral submucous fibrosis |
| Date: | 2017-03 |
| Issue Date: | 2019-05-31T03:54:29Z (UTC)
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| Publisher: | Wiley Online Library |
| ISSN: | 1600-0714 |
| Abstract: | Background
Oral submucous fibrosis (OSF) is one of the well‐recognized oral potentially malignant disorders. In this study, we investigated the malignant transformation of OSF in a Taiwanese population.
Methods
A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. A comparison cohort was randomly frequency‐matched with the OSF cohort according to age, sex, and index year. Oral leukoplakia (OL) was further stratified to evaluate for the possible synergistic effects of OSF‐associated malignant transformation.
Results
In this cohort, 71 (9.13%) of 778 cases of OSF were observed to transform into oral cancer. The malignant transformation rate was 29.26‐fold in the OSF cohort than in the comparison cohort after adjustment (95% confidence intervals 20.55‐41.67). To further stratify with OL, OSF with OL (52.46%; 95% confidence intervals 34.88‐78.91) had higher risk of malignant transformation rate than OSF alone (29.84%; 95% confidence intervals 20.99‐42.42). The Kaplan‐Meier plot revealed the rate free of malignant transformation was significant over the 13‐year follow‐up period (log‐rank test, P<.001). The mean duration of malignant transformation was 5.1, 2.7, and 2.2 years for non‐OSF, OSF alone, and OSF with OL, respectively.
Conclusion
Oral submucous fibrosis patients exhibited a significantly higher risk of malignant transformation than those without OSF. OL could enhance malignant transformation in patients with OSF. |
| URI: | https://ir.csmu.edu.tw:8080/ir/handle/310902500/20207 |
| Relation: | Journal of Oral Pathology & Medicine, vol.16, issue 10, 1040-1045 |
| Appears in Collections: | [口腔醫學研究所] 期刊論文
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| Yang_et_al-2017-Journal_of_Oral_Pathology_&_Medicine.pdf | | 266Kb | Adobe PDF | 164 | View/Open |
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