Multiform TiO 2 nano-network enhances biological response to titanium surface for dental implant applications

doi:10.1016/j.apsusc.2018.11.244

中山醫學大學機構典藏 CSMUIR > 附設醫院 > 期刊論文 > Item 310902500/19919

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19919

Title:	Multiform TiO 2 nano-network enhances biological response to titanium surface for dental implant applications
Authors:	Yang, W.-E.
Date:	2019-03
Issue Date:	2019-03-19T03:31:30Z (UTC)
ISSN:	01694332
Abstract:	Our objective in this study was to evaluate biological responses to a unique multiform nano-network of TiO 2 on a titanium (Ti) surface for dental implant applications. A novel multiform TiO 2 nano-network was formed on the anodized Ti surface using a simple, rapid electrochemical anodization process. The size of the pores in the nano-network ranged from a few nanometers to a few hundred nanometers. Human bone marrow mesenchymal stem cells (hBMSCs) were used as a model in this study. The multiform nanostructure, which is on the scale of various biological species, was shown to enhance protein adsorption, cell motility, cell proliferation, cell differentiation, and surface bioactivity, as well as stimulate outside-in signals via integrins and the formation of focal adhesion complex. It was also shown to promote hBMSCs toward the osteogenic differentiation pathway and convert the Ti surface from bioinert to bioactive. This is a clear indication that the proposed multilayer TiO 2 nano-network has excellent biocompatibility and surface bioactivity. The bioactive TiO 2 nano-network structure introduced in this study has considerable potential for applications in implant dentistry. © 2018 Elsevier B.V.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/19919
Relation:	Applied Surface Science Volume 471, 31 March 2019, Pages 1041-1052
Appears in Collections:	[附設醫院] 期刊論文

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