中山醫學大學機構典藏 CSMUIR:Item 310902500/1989
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17918/22933 (78%)
造访人次 : 7493479      在线人数 : 322
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/1989


    题名: 廣東住血線蟲症引起之血腦障壁損傷與基質金屬蛋白之關係
    Association of Matrix Metalloproteinases with blood-brain Barrier Damage of Angiostrongyliasis
    作者: 陳科銘;李秀雄;蔡博全;陳坤志;賴世展
    Ke-Min Chen;Hsiu-Hsiung Lee;Bo-Cyuan Tsai;Kung-Chih Chen;Shih-Chan Lai
    贡献者: 中山醫學大學
    关键词: 廣東住血線蟲;基質金屬蛋白2;基質金屬蛋白9;嗜伊紅性腦膜炎;血腦障壁
    Angiostrongylus cantonensis;MMP-2;MMP-9;eosinophilic meningitis;BBB
    日期: 2004-12-01
    上传时间: 2010-08-03T06:32:15Z (UTC)
    出版者: 教務處出版組
    摘要: 血腦障壁(blood-brain barrier; BBB)被視為腦膜炎的重要病理生理因素，此屏障的損傷會造成白血球浸潤至蜘蛛膜下腔。基質金屬蛋白(matrix metalloproteinases, MMPs)涉及許多中樞神經系統的發炎性疾病，其中MMP-9的過度分解會造成BBB的破壞。本研究結果顯示腦脊髓液(cerebrospinal fluid; CSF)中之MMP-9的酵素活性只在感染廣東住血線蟲誘發嗜伊紅性腦膜炎的小白鼠檢測到此酵素，而未感染組則無法檢測到此酵素。浸潤至CSF中之嗜伊紅性白血球數量與MMP-9活性及CSF之總蛋白濃度明顯相關。相對地，MMP-2出現在所有的CSF檢體，包括未感染的小白鼠，且酵素活性並無改變。此結果顯示MMP-2酵素活性與CSF中之嗜伊紅性白血球數量及CSF之總蛋白濃度並無明顯相關。另外，以MMPs專一的抑制劑GM6001處理後，MMP-9酵素活性及CSF總蛋白濃度皆明顯降低。這些結果顯示MMP-9可能與廣東住血線蟲症引起之BBB損傷有關。
    Blood-brain barrier (BBB) breakdown, causing extravasation of leukocytes into subarachnoid space, is regarded as an important pathophysiological event in meningitis. Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of various inflammatory diseases of the central nervous system. Excessive proteolytic activity of MMP-9 can be detrimental, leading to the disruption of the BBB. The present study showed that the activities of MMP-9 in the cerebrospinal fluid (CSF) were significantly increased in mice with eosinophilic meningitis compared with uninfected mice. CSF eosinophilia was significantly correlated with MMP-9 intensity and CSF total protein. In contrast, MMP-2 was presented and remain unchanged in all CSF samples showing that this enzyme was not correlated with CSF eosinophilia and CSF total protein. In addition, MMP-9 enzymatic activity and CSF total protein were significantly increased upon the establishment of infection but subsided due to an inhibition by GM6001, a specific inhibitor for MMPs, These results suggested that MMP-9 proteolytic activity may be associated with BBB disruption in angiostrongyliasis.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/1989
    關聯: 中山醫學雜誌, v15 n.2 p195-204
    显示于类别:[教務處] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML561检视/开启


    SFX Query

    在CSMUIR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈