中山醫學大學機構典藏 CSMUIR:Item 310902500/19897
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    题名: Flunarizine related movement disorders: a nationwide population-based study
    作者: Jhang, K.-M.
    Huang, J.-Y.
    Nfor, O.N.
    Ku, W.-Y.
    Liaw, Y.-P.
    贡献者: 中山醫學大學公共衛生學系（所）
    日期: 2019-03
    上传时间: 2019-03-12T03:09:28Z (UTC)
    ISSN: 20452322
    摘要: Flunarizine (fz) causes side effects such as movement disorders (MDs). We investigated risk factors associated with fz-related MDs. Participants were recruited from the longitudinal health insurance databases and included patients who took fz for more than 1 month. Patients with one of the underlying diseases, or with concomitant drug use (antipsychotics, metoclopramide or reserpine), and those diagnosed with MDs before fz use were excluded. Fz-related MD was defined as a new diagnosis of parkinsonism or hyperkinetic syndrome including dyskinesia or secondary dystonia during fz use or within 3 months after drug discontinuation. After exposure, 288 individuals had fz-related MDs (parkinsonism, n = 240; hyperkinesia, n = 48). Risk factors associated with these disorders were higher-dose exposure (cumulative defined daily dose [cDDD] ≥87.75, odds ratio [OR]: 3.80; 95% CI: 2.61–5.52), older age (OR: 1.07; 95% CI: 1.06–1.09), history of essential tremor (OR: 6.39; 95% CI: 2.29–17.78) and cardiovascular disease (CVD) (OR: 1.47; 95% CI: 1.14–1.9). The optimal value of cDDD to predict MDs was 58.5 (sensitivity: 0.67, specificity: 0.60), indicating an overall exposure of 585 mg. Higher exposure dose and duration, older age, history of essential tremor, and CVD were associated with fz-associated MDs. Clinicians ought to watch for extrapyramidal side effects when prescribing fz. © 2019, The Author(s).
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19897
    關聯: Scientific Reports Volume 9, Issue 1, 1 December 2019
    显示于类别:[公共衛生學系暨碩士班] 期刊論文

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