| Abstract: | 本研究的目的在比較鉈-201(TI-201)單光子電腦斷層造影(SPECT)和傳統的造影工具，包括電腦斷層攝影(CT)和磁振攝影(MRI)，在偵測殘餘或復發性口腔鱗狀細胞癌的有效性。共納入32位臨床上懷疑有復發性口腔鱗狀細胞癌的患者。所有患者均在2週內接受鉈-201 SPECT和CT或MRI的檢查。最終診斷是根據病理切片報告。鉈-201 SPECT和CT/MRI均精確地偵測到18位殘餘或復發腫瘤中的17位。CT/MRI報告中有8位陽性，而鉈-201 SPECT則成功地排除了所有腫瘤病例。用鉈-201 SPECT偵測復發性口腔鱗狀細胞癌的敏感性、特異性、陽性預期值、陰性預期值和精確度分別94%，100%，100%，93%和97%。而用CT/MRI偵測復發性口腔鱗狀細胞癌的敏感性、特異性、陽性預期值、陰性預期值和精確度分別94%，43%，68%，86%和72%。在分辨殘餘或復發性口腔鱗狀細胞癌和治療後的變化上，鉈-201 SPECT較傳統造影工具（CT或MRI）更精確。
This study was designed to compare the effectiveness of thallium-201 single photon emission computed tomography (SPECT) and conventional imaging, i.e. computed tomography (CT) and magnetic resonance imaging (MRI), in the detection of residual/recurrent squamous cell carcinoma (SCC) of the oral cavity. Thirty-two patients with clinically suspected recurrent SCC of the oral cavity were recruited. All patients underwent thallium-201 SPECT and CT or MRI within 2 weeks. The final diagnoses were based on the histology of biopsy specimen. TI-201 SPECT and CT/MRI both accurately detected 17 of 18 residual/recurrent tumors. CT/MRI had 8 false-positive studies, whereas Tl-201 SPECT successfully excluded all tumors. The sensitivity, specificity, positive and negative predictive values, and accuracy of Tl-201 SPECT for the detection of recurrent oral SCC were 94%, 100%, 100%, 93%, and 97%, respectively. The sensitivity, specificity, positive and negative predictive values, and accuracy of CT/MRI for the detection of recurrent oral SOC were 94%, 43%, 68%, 86%, and 72%, respectively. Thallium-201 SPECT is more accurate than conventional imaging (CT or MRI) in differentiating residual/recurrent oral SCC from post-therapy changes. |
