結論與建議：本研究發現失智症的主要危險因素為慢性疾病，骨關節炎患者暴露於手術或不同麻醉方式對於增加罹患失智症風險並無差別。
Abstract
Objective：
Dementia is one of the most common neurological diseases around the world, but it remains unclear whether there is an association between dementia and general anaesthesia. This study aimed to investigate the association between anaesthesia and dementia in osteoarthritis patients by analyzing a nation-wide population-based database.
Methods and Materials：
Using the claims data of 1 million insured residents covered by Taiwan’s universal health insurance from 2000 to 2013, we included 2171 newly diagnosed dementia patients for the study group. The control group, which consisted of 4342 individuals without dementia, was matched for age and gender. Data were analyzed using logistic regression.
Results：
There were no difference between Individuals exposed to general anaesthesia and those exposed to regional anaethesia (OR = 1.11, 95%CI 0.73-1.70) after adjusted for age, sex and Co-morbidities. In addition, no significant association was found when exposure was quantified as anaesthesia duration(OR = 0.91, 1.21, and 0.39 for <2 hours, 2-4hours, >4hours exposures compared to none, respectively) or replacement time(OR = 0.72 for twice compared to once).
Conclusion and Suggestion：
The results of our nationwide, population-based study show that there is no significant difference of dementia risk after either general or regional anaesthesia.
