Rubus idaeus extract suppresses migration and invasion of human oral cancer by inhibiting MMP‐2 through modulation of the Erk1/2 signaling pathway

doi:10.1002/tox.22302

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/19406

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19406

Title:	Rubus idaeus extract suppresses migration and invasion of human oral cancer by inhibiting MMP‐2 through modulation of the Erk1/2 signaling pathway
Authors:	Huang, Yi‐Wen;Chuang, Chun‐Yi;Hsieh, Yih‐Shou;Chen, Pei‐Ni;Yang, Shun‐Fa;Lin, Shih‐Hsuan;Chen, Yang‐Yu;Lin, Chiao‐Wen;Chang, Yu‐Chao
Contributors:	中山醫學大學口腔醫學研究所
Keywords:	Rubus idaeus;MMP‐2;migration;oral cancer
Date:	2016-06-20
Issue Date:	2018-10-17T07:35:54Z (UTC)
Abstract:	Raspberries (Rubus idaeus L.) have been extensively studies worldwide because of their beneficial effects on health. Recently reports indicate that crude extracts of Rubus idaeus (RIE) have antioxidant and anticancer ability. The aim of this study was to evaluate the mechanism of its antimetastatic ability in oral cancer cells. In this study, SCC‐9 and SAS oral cancer cells were subjected to a treatment with RIE and then analyzed the effect of RIE on migration and invasion. The addition of RIE inhibited the migration and invasion ability of oral cancer cells. Real time PCR, western blot and zymography analysis demonstrated that mRNA, protein expression and enzyme activity of matrix metalloproteinases‐2 (MMP‐2) were down‐regulated by RIE. Moreover, the phosphorylation of Focal adhesion kinase (FAK), src, and extracellular signal‐regulated kinase (ERK) were inhibited after RIE treatment. In conclusion, these results demonstrated that RIE exerted an inhibitory effect of migration and invasion in oral cancer cells and alter metastasis by suppression of MMP‐2 expression through FAK/Scr/ERK signaling pathway. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1037–1046, 2017.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/19406
Relation:	Environmental Toxicology vol.32, Issue.3,1037-1046
Appears in Collections:	[口腔醫學研究所] 期刊論文

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