中山醫學大學機構典藏 CSMUIR:Item 310902500/19397
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17938/22957 (78%)
造访人次 : 7402970      在线人数 : 111
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19397


    题名: Inhibitory effects of Leucaena leucocephala on the metastasis and invasion of human oral cancer cells
    作者: Chung, Hsiao‐Hang;Chen, Mu‐Kuan;Chang, Yu‐Chao;Yang, Shun‐Fa;Lin, Chia‐Chieh;Lin, Chiao‐Wen
    贡献者: 中山醫學大學口腔醫學院
    关键词: Leucaena leucocephala;MMP‐2;migration;oral cancer
    日期: 2017-02-09
    上传时间: 2018-09-28T04:57:15Z (UTC)
    摘要: Oral cancer is one of the most common cancers worldwide, and metastasis is recognized as a major factor causing its low survival rate. The inhibition of metastasis progress and the improvement of the survival rate for oral cancer are critical research objectives. Leucaena leucocephala from the mimosa branch Leucaena genus is native to Central and South America and has been used as a traditional remedy for treating various disorders. Previous studies have demonstrated antioxidant, anti‐inflammatory as well as anticancer properties of L. leucocephala plant materials. However, the molecular mechanism underlying the anticancer effect induced by L. leucocephala remains unclear. In this study, we investigated the effect of L. leucocephala extract (LLE) on SCC‐9 and SAS oral cancer cells and examined the potential inhibitory mechanisms involved. The results indicated that LLE attenuated the migration and invasion abilities of both SCC‐9 and SAS cells by reducing the activity and protein expression of matrix metalloproteinases‐2 (MMP‐2). Regarding mitogen‐activated protein kinase (MAPK) pathways, the phosphorylation of ERK1/2 and p38 exhibited a significant inhibitory effect in the presence of LLE. The application of ERK inhibitor and p38 inhibitor confirmed that both signalling transduction pathways were involved in the inhibition of cell metastasis. These data indicate that L. leucocephala could be a potent therapeutic agent for the prevention and treatment of oral cancer and a prominent plant source for anticancer research in the future.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19397
    關聯: Environ Toxicol. 2017 Jun;Vol.31,Issue 6
    显示于类别:[口腔醫學研究所] 期刊論文

    文件中的档案:

    没有与此文件相关的档案.



    检视Licence

    SFX Query

    在CSMUIR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈