Rubus idaeus Inhibits Migration and Invasion of Human Nasopharyngeal Carcinoma Cells by Suppression of MMP-2 through Modulation of the ERK1/2 Pathway.

doi:10.1142/S0192415X17500847

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/19396

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题名:	Rubus idaeus Inhibits Migration and Invasion of Human Nasopharyngeal Carcinoma Cells by Suppression of MMP-2 through Modulation of the ERK1/2 Pathway.
作者:	CH, Hsin CC, Huang PN, Chen YS, Hsieh SF, Yang YT, Ho CW, Lin
贡献者:	中山醫學大學口腔醫學院
关键词:	MMP-2;Metastasis;Nasopharyngeal Carcinoma;Rubus idaeus
日期:	2017-09-26
上传时间:	2018-09-28T04:46:57Z (UTC)
ISSN:	1557-1572
摘要:	Nasopharyngeal carcinoma (NPC) is characterized by a high incidence of metastasis in the neck lymph nodes, resulting in a poor prognosis and posing challenges for treatment. In this study, we investigated the in vitro antimetastatic properties of Rubus idaeus extract (RIE) on human nasopharyngeal carcinoma cells. HONE-1, NPC-39 and NPC-BM cells were subjected to RIE treatment, and effects on the migration and invasion of tumor cells were analyzed. The results showed that RIE suppressed the migration and invasion of NPC cells. Gelatin zymography assay, Western blotting and real-time PCR showed that matrix metalloproteinases-2 (MMP-2) enzyme activity, protein expression and mRNA levels were down-regulated by RIE treatment. To identify the signaling pathway, mitogen-activated protein kinase proteins were examined, which showed that phosphorylation of ERK1/2 was inhibited after the treatment of RIE. In summary, our data showed that RIE inhibited the migration and invasion of NPC cells by suppressing the expression of MMP-2 by down-regulating the ERK1/2 signaling pathway, suggesting that Rubus idaeus may serve as chemotherapeutic and chemopreventive agent for NPC.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/19396
關聯:	The American Journal of Chinese Medicine, Vol.45, No.7
显示于类别:	[口腔醫學研究所] 期刊論文

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