Functional FGFR4 Gly388Arg polymorphism contributes to oral squamous cell carcinoma susceptibility

doi:10.18632/oncotarget.21958

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/19395

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19395

Title:	Functional FGFR4 Gly388Arg polymorphism contributes to oral squamous cell carcinoma susceptibility
Authors:	Chou, Chia-Hsuan Hsieh, Ming-Ju Chuang, Chun-Yi Lin, Jen-Tsun Yeh, Chia-Ming Tseng, Pao-Yu Yang, Shun-Fa Chen, Mu-Kuan Lin, Chiao-Wen
Contributors:	中山醫學大學口腔醫學院
Keywords:	FGFR4;polymorphism;OSCC;metastasis;betel quid chewing
Date:	2017-11-10
Issue Date:	2018-09-28T04:33:50Z (UTC)
ISSN:	1949-2553
Abstract:	Aberrations of the fibroblast growth factor receptor 4 (FGFR4) genomic region include amplification of FGFR4, activation of FGFR4 kinase domain mutations, and overexpression of FGFR4, which lead to sustained cell proliferation and contribute to tumor development. However, the association between FGFR4 single-nucleotide polymorphisms (SNPs) and risk of oral squamous cell carcinoma (OSCC) remains to be determined. We investigated the relationships between FGFR4 genetic polymorphisms, OSCC development and clinicopathological variables. We recruited a total of 955 patients with OSCC and 1191 controls. Four SNPs of FGFR4 (rs2011077, rs351855, rs7708357, and rs1966265) were examined using real-time polymerase chain reaction. We found that with the rs351855 GA genotype and a combination of the GA and AA genotypes exhibited a 1.431-fold (95% CI: 1.092-1.876) and 1.335-fold (95% CI: 1.033-1.725) higher risk of OSCC. However, patients with OSCC with a homozygous A/A genotype of FGFR4 rs351855 polymorphism had a lower risk of advanced stage OSCC (P = 0.0252). Furthermore, the patients with the FGFR4 rs351855/rs1966265 A-A haplotype had a 2.890-fold (95% confidence interval [CI]: 2.257–3.700) higher risk of OSCC than the controls. Betel quid chewers with the A-A haplotype had a considerably higher risk (95% CI: 16.159–26.937) of OSCC than did betel quid nonchewers with other haplotypes. Moreover, an additional integrated in silico analysis proposed that rs351855 G allele variant to the A allele exhibited a relatively low energy of the transmembrane region. In conclusion, our results suggest that the FGFR4 rs351855 may play a role in susceptibility for OSCC development.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/19395
Relation:	Oncotarget. 2017 Nov 10; 8(56): 96225–96238
Appears in Collections:	[口腔醫學研究所] 期刊論文

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