MMP-11 promoted the oral cancer migration and FAK/Src activation

doi:10.18632/oncotarget.15824

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/19394

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题名:	MMP-11 promoted the oral cancer migration and FAK/Src activation
作者:	Hsin, Chung-Han Chou, Ying-Erh Yang, Shun-Fa Su, Shih-Chi Chuang, Yi-Ting Lin, Shu-Hui Lin, Chiao-Wen
贡献者:	中山醫學大學口腔醫學院
关键词:	matrix metalloproteinase;oral squamous cell carcinoma;metastasis;survival;FAK/Src pathway
日期:	2017-05-16
上传时间:	2018-09-28T04:27:38Z (UTC)
摘要:	Matrix metalloproteinase-11 (MMP-11) has been observed in most invasive human carcinomas. The current study investigated the association between the clinicopathological characteristics and MMP-11 expression in oral squamous cell carcinoma (OSCC) patients. Immunohistochemistry (IHC) staining was performed to assess MMP-11 expression in 279 patients with OSCC. In addition, the metastatic effects of the MMP-11 overexpression on the OSCC cells were also investigated. We found that MMP-11 expression was present in 118/279 (42.3%) cases and expression of MMP-11 was associated with higher incidence of lymph node metastasis and worse grade of tumor differentiation. Importantly, OSCC patients with strong expression of MMP-11 had a significantly lower survival rate (p=0.010). Furthermore, MMP-11 overexpression in OSCC cells increased in vitro cell migration. Mechanistically, MMP-11 increased the cell motility of OSCC cells through focal adhesion kinase/Src kinase (FAK/Src) pathway. In conclusion, our results revealed that the MMP-11 expression in OSCC samples can predict the progression, especially lymph node metastasis, and the survival of OSCC patients in Taiwan.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/19394
關聯:	Oncotarget. 2017 May 16; 8(20): 32783–32793.
显示于类别:	[口腔醫學研究所] 期刊論文

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