Cytomegalovirus disease after liver transplantation: a nationwide population-based study

doi:10.1016/j.transproceed.2013.12.009

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/19295

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题名:	Cytomegalovirus disease after liver transplantation: a nationwide population-based study
作者:	PY, Liu SB, Cheng CC, Lin CH, Lin SN, Chang CY, Cheng ZY, Shi KC, Tung MJ, Wu
贡献者:	中山醫學大學
日期:	2014-04
上传时间:	2018-06-22T05:09:38Z (UTC)
出版者:	Transplant Proc
ISSN:	0041-1345
摘要:	BACKGROUND: Cytomegalovirus (CMV) disease is a significant complication after liver transplantation. The estimated incidence varies among studies, which have been conducted in single regional centers and with small cohorts. In this study, we investigated the occurrence of CMV disease among liver transplant recipients in a national cohort in Taiwan. METHODS: This retrospective study used data from the Taiwan National Health Insurance Research Database. All liver transplant recipients in the catastrophic illness database from 2000 to 2009 were enrolled. Cases of CMV disease were identified from the admission database with the use of the ICD-9-CM code 078. RESULTS: The national cohort consisted of 1,721 liver transplant recipients (1,200 men and 521 women) with a mean age of 43.9 ± 8.9 years at the time of transplantation. The mean follow-up duration was 3.6 ± 2.7 years. The mortality rate was 14.9% at 1 year and 20.5% at 5 years. During the study period, 84 patients (4.9%) were diagnosed with CMV disease. The overall prevalence of CMV disease was 14.5 per 100 person-years. The cumulative incidences of post-transplantation CMV infection at 3 months, 6 months, 1 year, 2 years, 5 years, and 10 years were 1.2%, 2.7%, 3.8%, 4.2%, 4.8%, and 4.9%, respectively. The most common CMV-related diseases were colitis, hepatitis, and pneumonia. CONCLUSIONS: The risk of CMV disease was significantly elevated in the first 6 months after liver transplantation in the Taiwanese cohort.
URI:	http://dx.doi.org/10.1016/j.transproceed.2013.12.009 https://ir.csmu.edu.tw:8080/ir/handle/310902500/19295
關聯:	Transplant Proc. 2014 Apr;46(3):832-4
显示于类别:	[醫學系] 期刊論文

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