Effects of HMGB1 Polymorphisms on the Susceptibility and Progression of Hepatocellular Carcinoma

doi:10.7150/ijms.14877

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 生物醫學科學學系暨碩士班 > 期刊論文 > Item 310902500/19254

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题名:	Effects of HMGB1 Polymorphisms on the Susceptibility and Progression of Hepatocellular Carcinoma
作者:	Wang, B CB, Yeh MY, Lein CM, Su SF, Yang YF, Liu CH, Tang
贡献者:	中山醫學大學
关键词:	HCC;HMGB1;SNP;Susceptibility
日期:	2016-04
上传时间:	2018-06-21T08:48:06Z (UTC)
出版者:	Int J Med Sci
ISSN:	1449-1907
摘要:	Hepatocellular carcinoma (HCC) is a malignancy of liver and a leading cause of cancer mortality worldwide. Its management is compounded by biological and clinical heterogeneity. These interindividual genetic variations can modulate the effects of HCC treatment. High-mobility group box protein 1 (HMGB1) is a well investigated, ubiquitous nuclear protein found in eukaryotic cells that plays a multiple biological roles such as DNA stability, program cell death, immune response, and furthermore in cancer progression. In this report, we examined HMGB1 single nucleotide polymorphisms (SNPs) with multiple risk factors related to HCC susceptibility and clinicopathological characteristics. Four HMGB1 SNPs (rs1412125, rs2249825, rs1045411, and rs1360485) were assessed by using a TaqMan SNPs Genotyping in 324 patients with HCC and in 695 cancer-free controls. The results showed that HMGB1 SNP rs1045411 with CT or at least one T alleles has lower risk of HCC than wild-type (CC) carriers. Moreover, HMGB1 SNP rs1412125 with TT allele has a higher risk of distant metastasis compared with patients carrying at least one C allele. The present study is the first report to discuss the risk factors associated with HMGB1 SNPs in HCC progression in Taiwan.
URI:	http://dx.doi.org/10.7150/ijms.14877 https://ir.csmu.edu.tw:8080/ir/handle/310902500/19254
關聯:	Int J Med Sci. 2016 Apr 9;13(4):304-9
显示于类别:	[生物醫學科學學系暨碩士班] 期刊論文

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