Downregulation of miR-1 enhances tumorigenicity and invasiveness in oral squamous cell carcinomas

doi:10.1016/j.jfma.2016.12.003

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 博碩士論文 > Item 310902500/19228

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19228

Title:	Downregulation of miR-1 enhances tumorigenicity and invasiveness in oral squamous cell carcinomas
Authors:	CY, Peng YW, Liao MY, Lu CH, Yu CC, Yu MY, Chou
Contributors:	中山醫學大學
Keywords:	invasiveness;miR-1;oral squamous cell carcinomas
Date:	2017-10
Issue Date:	2018-06-20T08:57:47Z (UTC)
Publisher:	Journal of the Formosan Medical Association
ISSN:	http://dx.doi.org/10.1016/j.jfma.2016.12.003 0929-6646
Abstract:	BACKGROUND/PURPOSE: Cumulative evidence suggest that microRNAs (miRNAs) function as biosignatures of oral squamous cell carcinomas (OSCC). However, the functional roles of miR-1 as well as its downstream targets in the regulation of tumorigenicity in OSCC remain unclear. METHODS: miRNAs RT-PCR analysis was performed to identify miR-1 as a putative candidate on mediating invasiveness of OSCC cells. Consequently, we elucidated the tumorigenicity of OSCC cells with miR-1 downregulation or overexpression, respectively. Finally, miR-1 on OSCC tumor tissues was examined. RESULTS: miR-1 levels were significantly downregulated in the malignant OSCC cells. Overexpression of miR-1 significantly reduced migration/invasiveness of OSCC cells. In addition, overexpression of miR-1 decreased cancer stem cells properties. Conversely, downregulation of miR-1 promotes migration and invasiveness in OSCC cells. We have shown that miR-1 is able to target Slug, suppressing their expression. Clinically, lower miR-1 expression was found in patients with advanced nodal metastasis OSCC. CONCLUSION: miR-1 as novel biosignatures in OSCC lymph node metastatic patients, supporting the development of novel strategies for OSCC treatment.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/19228
Relation:	Journal of the Formosan Medical Association, 2017-10-01, 卷 116, 期 10, 頁面 782-789
Appears in Collections:	[牙醫學系暨碩士班] 博碩士論文

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