The correlation between HIF-1 alpha and VEGF in oral squamous cell carcinomas: Expression patterns and quantitative immunohistochemical analysis

doi:10.1016/j.jcma.2017.06.025

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/19057

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19057

Title:	The correlation between HIF-1 alpha and VEGF in oral squamous cell carcinomas: Expression patterns and quantitative immunohistochemical analysis
Authors:	LT, Lee YK, Wong MY, Chan KW, Chang SC, Chen CT, Chang Wang, J
Contributors:	中山醫學大學
Keywords:	Hypoxia-inducible factor-1 alpha;Immunohistochemistry Oral squamous cell carcinoma;Quantitation;Vascular endothelial growth factor
Date:	2018-04
Issue Date:	2018-03-27T09:19:00Z (UTC)
Publisher:	Elsevier Ltd
ISSN:	17264901
Abstract:	Background: The prognostic predict biomarkers are important in oral squamous cell carcinoma (OSCC). We investigated the expression patterns and quantitation of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in OSCC patients. Among OSCC patients with recurrence and metastasis, the expression percentages of HIF-1α and VEGF also were analyzed. Methods: Thirty-eight patients (8 hyperkeratosis, 30 oral squamous cell carcinoma) were included in this study. In the follow-up period, 5 OSCC patients had metastasis and 12 OSCC patients had local recurrence. We used computer-assisted image processing to analyze immunohistochemistry (IHC). The quantitative analysis of IHC slides, including upper-layer epithelium (U) and lower-layer epithelium (L), was calculated. Results: We found homogeneous expression of VEGF in the epithelium. However, two patterns of HIF-1α expression were observed: homogeneous and heterogeneous. The highest U + L layer percentage in HIF-1α and VEF expression had significant association in tumor metastasis and recurrence (p < 0.001 in HIF-1α and p < 0.001 in VEGF). U + L layer HIF-1α expression percentage was >156.4%, and the survival rate was poor (p < 0.001). Conclusion: HIF-1α expression was not only influenced by tumor hypoxia, it also reflected tumor cell characteristics. High concentrations of VEGF and HIF-1α may have value as prognostic markers of tumor metastasis and recurrence. © 2017
URI:	https://www.doi.org/10.1016/j.jcma.2017.06.025 https://ir.csmu.edu.tw:8080/ir/handle/310902500/19057
Relation:	Journal of the Chinese Medical Association Volume 81, Issue 4, April 2018, Pages 370-375
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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