中山醫學大學機構典藏 CSMUIR:Item 310902500/19054
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17939/22958 (78%)
造访人次 : 7376519      在线人数 : 250
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19054


    题名: Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail
    作者: HW, Yang;MY, Lu;YW, Chiu;YW, Liao;YF, Huang;Ju, Chueh P;PL, Hsieh;CC, Yu
    贡献者: 中山醫學大學
    关键词: hinokitiol;myofibroblasts;precancerous oral submucous fibrosis;Snail;α-SMA
    日期: 2018-04
    上传时间: 2018-03-27T09:11:01Z (UTC)
    出版者: John Wiley and Sons Inc.
    ISSN: 15204081
    摘要: Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Treatment of hinokitiol dose-dependently downregulated the myofibroblast markers as well as various EMT transcriptional factors. In particular, we identified that Snail was able to bind to the E-box in the α-SMA promoter. Our data suggested that exposure of fBMFs to hinokitiol mitigated the hallmarks of myofibroblasts, while overexpression of Snail eliminated the effect of hinokitiol. These findings revealed that the inhibitory effect of hinokitiol on myofibroblasts was mediated by repression of α-SMA via regulation of Snail and showed the anti-fibrotic potential of hinokitiol in the treatment of OSF. © 2018 Wiley Periodicals, Inc.
    URI: https://www.doi.org/10.1002/tox.22531
    https://ir.csmu.edu.tw:8080/ir/handle/310902500/19054
    關聯: Environmental Toxicology Volume 33, Issue 4, April 2018, Pages 454-462
    显示于类别:[附設醫院] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML354检视/开启


    检视Licence

    SFX Query

    在CSMUIR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈