Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail

doi:10.1002/tox.22531

中山醫學大學機構典藏 CSMUIR > 附設醫院 > 期刊論文 > Item 310902500/19054

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19054

Title:	Hinokitiol ablates myofibroblast activation in precancerous oral submucous fibrosis by targeting Snail
Authors:	HW, Yang;MY, Lu;YW, Chiu;YW, Liao;YF, Huang;Ju, Chueh P;PL, Hsieh;CC, Yu
Contributors:	中山醫學大學
Keywords:	hinokitiol;myofibroblasts;precancerous oral submucous fibrosis;Snail;α-SMA
Date:	2018-04
Issue Date:	2018-03-27T09:11:01Z (UTC)
Publisher:	John Wiley and Sons Inc.
ISSN:	15204081
Abstract:	Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Treatment of hinokitiol dose-dependently downregulated the myofibroblast markers as well as various EMT transcriptional factors. In particular, we identified that Snail was able to bind to the E-box in the α-SMA promoter. Our data suggested that exposure of fBMFs to hinokitiol mitigated the hallmarks of myofibroblasts, while overexpression of Snail eliminated the effect of hinokitiol. These findings revealed that the inhibitory effect of hinokitiol on myofibroblasts was mediated by repression of α-SMA via regulation of Snail and showed the anti-fibrotic potential of hinokitiol in the treatment of OSF. © 2018 Wiley Periodicals, Inc.
URI:	https://www.doi.org/10.1002/tox.22531 https://ir.csmu.edu.tw:8080/ir/handle/310902500/19054
Relation:	Environmental Toxicology Volume 33, Issue 4, April 2018, Pages 454-462
Appears in Collections:	[附設醫院] 期刊論文

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