中山醫學大學機構典藏 CSMUIR:Item 310902500/18999
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    题名: Increased risk of coronary heart disease among patients with primary Sjögren's syndrome: A nationwide population-based cohort study
    作者: Wu, Xue-Fen;Huang, Jing-Yang;Chiou, Jeng-Yuan;Chen, Huang-Hsi;Wei, James Cheng-Chung;corresponding;Dong, Ling-Li
    贡献者: 中山醫學大學
    日期: 2018-12-01
    上传时间: 2018-03-21T10:14:49Z (UTC)
    出版者: Nature Publishing Group
    ISSN: 20452322
    摘要: To investigate the association between primary Sjögren’s syndrome (pSS) and coronary heart disease (CHD), and the influence of medications for pSS patients on risk of CHD. The authors identified 4175 patients with a new diagnosis of pSS between 2002 and 2013 from the National Health Insurance Research database. The control-to-case ratio was 4:1. The risk and cumulative incidences of CHD were calculated. The adjusted hazard ratio (HR) of CHD for pSS patients was 1.17 (1.03–1.34) after adjusting for age, sex, comorbidities, and medications. The cumulative incidence for CHD in the pSS group was significantly higher than that in the control group (log-rank p < 0.0001). The risk of CHD in pSS patients was increased with age by 4% per year, and 45- to 59-year-olds were at the highest risk (HR = 1.464, 1.195–1.794). The application of corticosteroids (HR = 1.45, 1.07–1.97) as well as NSAIDs (HR = 1.31, 1.05–1.65) both increased the risk of CHD among pSS patients. pSS is associated with an increased risk of subsequent CHD in Taiwan. Primary Sjögren’s syndrome might be an independent risk factor for CHD. Use of corticosteroids and NSAIDs in the treatment of pSS patients increased the risk of developing CHD.
    URI: https://www.doi.org/10.1038/s41598-018-19580-y
    https://ir.csmu.edu.tw:8080/ir/handle/310902500/18999
    關聯: Scientific Reports Volume 8, Issue 1, 1 December 2018, 論文編號 2209
    显示于类别:[附設醫院] 期刊論文

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