Functional engineered mesenchymal stem cells with fibronectin-gold composite coated catheters for vascular tissue regeneration

doi:10.1016/j.nano.2017.12.023

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/18998

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18998

Title:	Functional engineered mesenchymal stem cells with fibronectin-gold composite coated catheters for vascular tissue regeneration
Authors:	YW, Chen;SC, Hsieh;YC, Yang;SH, Hsu;ML, Kung;PY, Lin;HH, Hsieh;CH, Lin;CM, Tang;HS, Hung
Contributors:	中山醫學大學
Keywords:	Mesenchymal stem cells;endothelialization, vascular tissue regeneration;fibronectin, gold nanoparticles
Date:	2018-04
Issue Date:	2018-03-21T10:09:26Z (UTC)
Publisher:	Elsevier Inc.
ISSN:	15499634
Abstract:	Vascularization of engineered tissues remains one of the key problems. Here, we described a novel approach to promote vascularization of engineered tissues using fibronectin (FN) incorporated gold nanoparticles (AuNP) coated onto catheters with mesenchymal stem cells (MSCs) for tissue engineering. We found that the FN-AuNP composite with 43.5 ppm of AuNP exhibited better biomechanical properties and thermal stability than pure FN. FN-AuNP composites promoted MSC proliferation and increased the biocompatibility. Mechanistically, vascular endothelial growth factor (VEGF) promoted MSC migration on FN-AuNP through the endothelial oxide synthase (eNOS)/metalloproteinase (MMP) signaling pathway. Vascular femoral artery tissues isolated from the implanted FN-AuNP-coated catheters with MSCs expressed substantial CD31 and alpha-smooth muscle actin (α-SMA), displayed higher antithrombotic activity, as well as better endothelialization ability than those coated with all other materials. These data suggested that the implantation of FN-AuNP-coated catheter with MSCs could be a novel strategy for vascular biomaterials applications. © 2018
URI:	https://www.doi.org/10.1016/j.nano.2017.12.023 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18998
Relation:	Nanomedicine: Nanotechnology, Biology, and Medicine Volume 14, Issue 3, April 2018, Pages 699-711
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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