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    Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18984


    Title: A three–MicroRNA signature as a potential biomarker for the early detection of oral cancer
    Authors: YA, Chang
    SL, Weng
    SF, Yang
    CH, Chou
    WC, Huang
    SJ, Tu
    TH, Chang
    CN, Huang
    YJ, Jong
    HD, Huang
    Contributors: 中山醫學大學
    Keywords: Biomarker;Early diagnosis;Leukoplakia;MiRNA;Oral cancer
    Date: 2018-03-07
    Issue Date: 2018-03-21T09:15:00Z (UTC)
    Publisher: MDPI AG
    ISSN: 16616596
    Abstract: Oral squamous cell carcinoma (OSCC) is often diagnosed at a late stage and may be malignantly transformed from oral leukoplakia (OL). This study aimed to identify potential plasma microRNAs (miRNAs) for the early detection of oral cancer. Plasma from normal, OL, and OSCC patients were evaluated. Small RNA sequencing was used to screen the differently expressed miRNAs among the groups. Next, these miRNAs were validated with individual samples by quantitative real-time polymerase chain reaction (qRT-PCR) assays in the training phase (n = 72) and validation phase (n = 178). The possible physiological roles of the identified miRNAs were further investigated using bioinformatics analysis. Three miRNAs (miR-222-3p, miR-150-5p, and miR-423-5p) were identified as differentially expressed among groups; miR-222-3p and miR-423-5p negatively correlated with T stage, lymph node metastasis status, and clinical stage. A high diagnostic accuracy (Area under curve = 0.88) was demonstrated for discriminating OL from OSCC. Bioinformatics analysis reveals that miR-423-5p and miR-222-3p are significantly over-expressed in oral cancer tissues and involved in various cancer pathways. The three-plasma miRNA panel may be useful to monitor malignant progression from OL to OSCC and as potential biomarkers for early detection of oral cancer. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
    URI: https://www.doi.org/10.3390/ijms19030758
    https://ir.csmu.edu.tw:8080/ir/handle/310902500/18984
    Relation: International Journal of Molecular Sciences Volume 19, Issue 3, 7 March 2018, 論文編號 758
    Appears in Collections:[附設醫院] 期刊論文

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