氧化鋯在臨床應用上被廣泛的使用因為氧化鋯擁有優異的機械性質以及良好的生物相容性，然而氧化鋯本身也有美中不足的地方像它的生物活性較不理想，因此在本實驗中，為了改善氧化鋯材料這項缺點，我們添加矽酸鈣與明膠來改善其生物活性。根據先前的文獻，我們利用氧化鋯作為基材，加添矽酸鈣來製造生物活性支架，其中以致孔劑來產生它的孔洞結構，接著在多孔支架的表層上塗上一層明膠。從實驗結果中我們可得知，根據致孔劑含量增加其支架的孔隙率從30%增加至40%，而強度的變化從330到120MPa，在經過浸泡模擬體液(SBF)中六個月後支架的強度減少，其強度範圍約150至100MPa，孔隙率約為40%至50%，除此之外，我們可在支架的表面上尋獲氫氧基磷灰石層，總結果所表示出此複合材料對於骨組織工程中，是相當具有潛力的組織工程再生材料。Zirconia is widely used for load-bearing applications because it has excellent mechanical properties and good biocompatibility. However, zirconia has some disadvantages such as poor bioactivity. In this study osteogenic calcium silicate and gelatin were added to the zirconia material to improve the bioactivity. Following the previous study, we fabricated calcium silicate-containing ZrO2 bulk materials, followed by the addition of porogen. A layer of gelatin was also coated on the porous scaffold surface. The results indicated that the porosity of the scaffolds was from 30% to 40% and the strength of the scaffold ranged from 330 to 120 MPa, depending on the porogen content. The scaffolds of soaking in SBF for 6 month. The strength of the scaffold was 100 and 150 MPa, the porosity of the scaffold was 40% and 50% of the different porosity. Moreover, We could discover the hydroxyapatite appeared on the surface of the scaffold. We could fabricate a porous ZrO2-based composite scaffold with excellent mechanical properties. The composite scaffold would be a promising bone tissue reconstruction material.
