Colchicine has long been employed to treat and prevent acute attacks of gout and also applied to a variety of conditions such us familial Mediterranean fever, Behcet's disease, and amyloidosis. Severe pancytopenia induced by therapeutic oral colchicines has been reported though rarely. However, there is current/v no recommended treatment.
We described a 78-year-old female with pancytopenia and bone marrow aplasia induced by oral colchicines and treated with granulocyte colony-stimulating factor (G-CSF) and erythropoietin (EPO). Pancytopenia and bone marrow aplasia eventually recovered after treatment.
Severe side effects of colchicine are rare, but may be more frequent among elderly patients with renal insufficiency and hepatic dysfunction. Treating colchicine-induced pancytopenia with combination of GCS-F and EPO may he effective.
秋水仙素常被用來治療及預防痛風的發作，以及使用在一些疾病，如家族性地中海型風濕熱、貝西氏症以及類澱粉沈著症。因使用治療劑量的秋水仙素所造成的全血球低下症實屬罕見。所以目前仍沒有建議的治療方式。
我們報告一位78歲慢性腎臟病的女性，因服用秋水仙素引起全血球低下症及骨髓再生不全，在使用顆粒球聚落刺激因子及紅血球生成素後血球恢復的個案。藉由此個案，我們回顧文獻後，了解年老及有肝腎疾病都是容易引起秋水仙素的血球毒性，以及此副作用可以給予顆粒球聚落刺激因子及紅血球生成素來治療。
