中山醫學大學機構典藏 CSMUIR:Item 310902500/18542
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    题名: Malignancy-associated chylothorax: a 20-year study of 18 patients from a single institution
    作者: CL, Teng
    KW, Li
    JT, Yu
    SL, Hsu
    RC, Wang
    WL, Hwang
    贡献者: 中山醫學大學
    日期: 2012-09
    上传时间: 2017-10-30T09:29:06Z (UTC)
    ISSN: 0961-5423
    摘要: Malignancy-associated chylothorax is a rare manifestation with uncertain characteristics and clinical significance. We segregated 18 patients into malignant lymphoma (n= 11) and solid malignancy (n= 7) groups to analyse the characteristics, treatment response and prognostic value of malignancy-associated chylothorax. Diagnosis of chylothorax was confirmed by a triglyceride concentration of >110 mg/dL or by the presence of chylomicrons in the pleural effusion. Concentrations of glucose, protein and lactate dehydrogenase did not differ significantly between the malignant lymphoma and solid malignancy groups. Although not statistically significant (P= 0.25), 90.9% malignant lymphoma patients and 57.1% solid malignancy patients had exudates. The cytology diagnostic rate in the malignant lymphoma and solid malignancy groups was 20.0% and 33.3% respectively (P > 0.99). After chemotherapy, six malignant lymphoma patients achieved complete remission, with simultaneous chylothorax disappearance. The overall survival rate at 12 and 24 months in the malignant lymphoma group was 54.5% and 36.4% respectively, while that in the solid malignancy group was 35.7% and 0% respectively. Malignant lymphoma was the chief cause of chylothorax in our cohort. Effective lymphoma treatment, lacking supplementary interventions, is essential for treating chylothorax in malignant lymphoma patients. Chylothorax indicates extremely limited life expectancy for solid malignancy patients.
    URI: http://dx.doi.org/10.1111/j.1365-2354.2012.01329.x
    https://ir.csmu.edu.tw:8080/ir/handle/310902500/18542
    關聯: Eur J Cancer Care (Engl). 2012 Sep;21(5):599-605.
    显示于类别:[醫學系] 期刊論文

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