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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/18540
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Title: | FBXW7 is involved in Aurora B degradation |
Authors: | Teng, Chieh-Lin Hsieh, Yun-Chi Phan, Liem Shin, Jihyun Gully, Chris Guermarie, Velazquez-Torres Skerl, Stephen Yeung, Sai-Ching J. Hsu, Shih-Lan Lee, Mong-Hong |
Contributors: | 中山醫學大學 |
Keywords: | p53;FBXW7;Aurora B;ubiquitination |
Date: | 2012-11 |
Issue Date: | 2017-10-30T09:22:34Z (UTC)
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ISSN: | 1538-4101 |
Abstract: | FBXW7, a component of E3 ubiquitin ligase, plays an important role in mitotic checkpoint, but its role remains unclear. Aurora B is a mitotic checkpoint kinase that plays a pivotal role in mitosis by ensuring correct chromosome segregation and normal progression through mitosis. Whether Aurora B and FBXW7 are coordinately regulated during mitosis is not known. Here, we show that FBXW7 is a negative regulator for Aurora B. Ectopic expression of FBXW7 can suppress the expression of Aurora B. Accordingly, FBXW7 deficiency leads to Aurora B elevation. Mechanistic studies show that all FBXW7 isoforms are negative regulators of Aurora B expression through ubiquitination-mediated protein degradation. Aurora B interacts with R465 and R505 residues of WD 40 domain of FBXW7. Significantly, inverse correlation between FBXW7 and Aurora B elevation is translated into the deregulation of mitosis. FBWX7 expression mitigates Aurora B-mediated cell growth and mitotic deregulation. In addition, FBXW7 reduces the percentage of multinucleated cells caused by Aurora B overexpression. These data suggest that FBXW7 is an important negative regulator of Aurora B, and that the loss or mutation of FBXW7 as seen in many types of cancer could lead to an abnormal elevation of Aurora B and result in deregulated mitosis, which accelerates cancer cell growth. |
URI: | http://dx.doi.org/10.4161/cc.22381 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18540 |
Relation: | Cell Cycle. 2012 Nov 1; 11(21): 4059–4068. |
Appears in Collections: | [醫學系] 期刊論文
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