Immunohistochemical localization of tissue-type plasminogen activator and type I plasminogen activator inhibitor in radicular cysts

doi:10.1111/j.0904-2512.2004.00133.x

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/18367

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题名:	Immunohistochemical localization of tissue-type plasminogen activator and type I plasminogen activator inhibitor in radicular cysts
作者:	Tsai, C.-H.;Weng, S.-F.;Yang, L.-C.;Huang, F.-M.;Chen, Y.-J.;Chang, Y.-C.
关键词:	Immunohistochemistry;Inflammation;Radicular cyst;Tissue-type plasminogen activator;Type I plasminogen activator inhibitor
日期:	2004
上传时间:	2017-08-14T08:48:49Z (UTC)
ISSN:	0904-2512
摘要:	BACKGROUND: The plasminogen/plasmin proteolytic system participates in a wide variety of extracellular matrix degradation. Detailed knowledge of plasminogen activators (PAs) and their inhibitors may be important for understanding the pathogenesis of radicular cysts. The purpose of this study was to investigate the in situ localization of tissue-type PA (t-PA) and type I PA inhibitor (PAI-1) in radicular cysts. METHODS: Thirty formalin-fixed, paraffin-embedded specimens of radicular cysts were examined using immunohistochemistry. In addition, another section from each radicular cyst specimen was stained with hematoxylin and eosin to assess the presence of inflammatory infiltrates. Differences in t-PA and PAI-1 expression between tissues with low and high levels of inflammation were subsequently analyzed using Fisher's exact test. RESULTS: Both t-PA- and PAI-1-positive cells were detected in the lining epithelium, connective tissue, inflammatory infiltrates, and endothelium. In addition, the t-PA signal was mainly expressed in epithelial cells. However, the PAI-1 signal was mainly expressed in fibroblasts. Moreover, significantly greater t-PA as well as PAI-I expression was noted in radicular cysts with high levels of inflammation as compared to tissues with low levels of Inflammatory cell infiltrates (P < 0.05). CONCLUSIONS: The present study confirms earlier indications of local production of PA and its inhibitor in radicular cysts. In addition, this study further shows the tissue localization of the antigens for t-PA as well as PAI-1, and demonstrates that the expression of both t-PA and PAI-1 increases with the grade of inflammation in radicular cysts.
URI:	http://dx.doi.org/10.1111/j.0904-2512.2004.00133.x https://www.scopus.com/inward/record.uri?eid=2-s2.0-1342323944&doi=10.1111%2fj.0904-2512.2004.00133.x&partnerID=40&md5=9b5a093d054224e081f1edb2961870ca https://ir.csmu.edu.tw:8080/ir/handle/310902500/18367
關聯:	Journal of Oral Pathology and Medicine 33 (3) ,156-161
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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