The synergistic effects of chinese herb and injectable calcium silicate/β-tricalcium phosphate composite on an osteogenic accelerator in vitro

doi:10.1007/s10856-015-5484-5

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/18227

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18227

Title:	The synergistic effects of chinese herb and injectable calcium silicate/β-tricalcium phosphate composite on an osteogenic accelerator in vitro
Authors:	Huang, M.-H.;Kao, C.-T.;Chen, Y.-W.;Hsu, T.-T.;Shieh, D.-E.;Huang, T.-H.;Shie, M.-Y.
Date:	2015
Issue Date:	2017-08-09T04:42:18Z (UTC)
Publisher:	Kluwer Academic Publishers
ISSN:	9574530
Abstract:	This study investigates the physicochemical and biological effects of traditional Chinese medicines on the β-tricalcium phosphate (β-TCP)/calcium silicate (CS) composites of bone cells using human dental pulp cell. CS is an osteoconductive and bioactive material. For this research we have combined β-TCP and CS and check its effectiveness, a series of β-TCP/CS composites with different ratios of Xu Duan (XD) were prepared to make new bioactive and biodegradable biocomposites for bone repair. XD has been used in Traditional Chinese Medicine for hundreds of years as an antiosteoporosis, tonic and antiaging agent for the therapy of low back pain, traumatic hematoma, threatened abortion and bone fractures. Formation of bone-like apatite, the diametral tensile strength, and weight loss of composites were considered before and after immersion in simulated body fluid (SBF). In addition, we also examined the effects of XD released from β-TCP/CS composites and in vitro human dental pulp cell (hDPCs) and studied its behavior. The results show the XD-contained paste did not give any demixing when the weight ratio of XD increased to 5–10 % due to the filter-pressing effect during extrusion through the syringe. After immersion in SBF, the microstructure image showed a dense bone-like apatite layer covered on the β-TCP/CS/XD composites. In vitro cell experiments shows that the XD-rich composites promote human dental pulp cells (hDPCs) proliferation and differentiation. However, when the XD quantity in the composite is more than 5 %, the amount of cells and osteogenesis protein of hDPCs were stimulated by XD released from β-TCP/CS composites. The combination of XD in degradation of β-TCP and osteogenesis of CS gives strong reason to believe that these calcium-based composite cements may prove to be promising bone repair materials. © 2015, Springer Science+Business Media New York.
URI:	http://dx.doi.org/10.1007/s10856-015-5484-5 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925263407&doi=10.1007%2fs10856-015-5484-5&partnerID=40&md5=139c9cd5d5f5378ca8b5ff38b0327043 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18227
Relation:	Journal of Materials Science: Materials in Medicine 26(4) ,-
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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