Mesoporous Calcium Silicate Nanoparticles with Drug Delivery and Odontogenesis Properties

doi:10.1016/j.joen.2016.09.012

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/18219

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18219

Title:	Mesoporous Calcium Silicate Nanoparticles with Drug Delivery and Odontogenesis Properties
Authors:	Huang, C.-Y.;Huang, T.-H.;Kao, C.-T.;Wu, Y.-H.;Chen, W.-C.;Shie, M.-Y.
Keywords:	Calcium silicate;dental pulp cell;drug delivery;mesoporous;odontogenic
Date:	2017
Issue Date:	2017-08-09T04:41:56Z (UTC)
Publisher:	Elsevier Inc.
ISSN:	992399
Abstract:	Introduction Calcium silicate (CS) –based materials play an important role in the development of endodontic materials that induce bone/cementum tissue regeneration and inhibit bacterial viability. The aim of this study was to prepare novel mesoporous CS (MesoCS) nanoparticles that have osteogenic, drug delivery, and antibacterial characteristics for endodontic materials and also have an excellent ability to develop apatite mineralization. Methods The MesoCS nanoparticles were prepared using sol-gel methods. In addition, the mesoporous structure, specific surface area, pore volume, and morphology of the MesoCS nanoparticles were analyzed. The apatite mineralization ability, in vitro odontogenic differentiation, drug delivery, and antibacterial properties of the MesoCS nanoparticles were further investigated. Results The results indicate that the 200-nm–sized MesoCS nanoparticles synthesized using a facile template method exhibited a high specific surface area and pore volume with internal mesopores (average pore size = 3.05 nm). Furthermore, the MesoCS nanoparticles can be used as drug carriers to maintain sustained release of gentamicin and fibroblast growth factor-2 (FGF-2). The MesoCS-loaded FGF-2 might stimulate more odontogenic-related protein than CS because of the FGF-2 release. Conclusions Based on this work, it can be inferred that MesoCS nanoparticles are potentially useful endodontic materials for biocompatible and osteogenic dental pulp tissue regenerative materials. © 2016 American Association of Endodontists
URI:	http://dx.doi.org/10.1016/j.joen.2016.09.012 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85004154278&doi=10.1016%2fj.joen.2016.09.012&partnerID=40&md5=7452f9a0d58fcb71b8da363000a3a0cc https://ir.csmu.edu.tw:8080/ir/handle/310902500/18219
Relation:	Journal of Endodontics 43(1) ,69-76
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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