Laser sintered magnesium-calcium silicate/poly-ε-caprolactone scaffold for bone tissue engineering

doi:10.3390/ma10010065

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/18217

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18217

Title:	Laser sintered magnesium-calcium silicate/poly-ε-caprolactone scaffold for bone tissue engineering
Authors:	Tsai, K.-Y.;Lin, H.-Y.;Chen, Y.-W.;Lin, C.-Y.;Hsu, T.-T.;Kao, C.-T.
Keywords:	Calcium silicate;Human marrow stem cells;Laser sintering;Osteogenesis;Scaffold
Date:	2017
Issue Date:	2017-08-09T04:41:50Z (UTC)
Publisher:	MDPI AG
ISSN:	19961944
Abstract:	In this study, we manufacture and analyze bioactive magnesium-calcium silicate/poly-"- caprolactone (Mg-CS/PCL) 3D scaffolds for bone tissue engineering. Mg-CS powder was incorporated into PCL, and we fabricated the 3D scaffolds using laser sintering technology. These scaffolds had high porosity and interconnected-design macropores and structures. As compared to pure PCL scaffoldswithout anMg-CS powder, the hydrophilic properties and degradation rate are also improved. For scaffolds with more than 20% Mg-CS content, the specimens become completely covered by a dense bone-like apatite layer after soaking in simulated body fluid for 1 day. In vitro analyses were directed using human mesenchymal stem cells (hMSCs) on all scaffolds that were shown to be biocompatible and supported cell adhesion and proliferation. Increased focal adhesion kinase and promoted cell adhesion behavior were observed after an increase inMg-CS content. In addition, the results indicate that the Mg-CS quantity in the composite is higher than 10%, and the quantity of cells and osteogenesis-related protein of hMSCs is stimulated by the Si ions released from the Mg-CS/PCL scaffolds when compared to PCL scaffolds. Our results proved that 3D Mg-CS/PCL scaffolds with such a specific ionic release and good degradability possessed the ability to promote osteogenetic differentiation of hMSCs, indicating that they might be promising biomaterials with potential for next-generation bone tissue engineering scaffolds. © 2017 by the authors.
URI:	http://dx.doi.org/10.3390/ma10010065 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011665214&doi=10.3390%2fma10010065&partnerID=40&md5=d882f92e34a76049d31e96852ac5a1aa https://ir.csmu.edu.tw:8080/ir/handle/310902500/18217
Relation:	Materials 10(1)
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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