Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired pneumonia

doi:10.1515/cclm.2011.805

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/18206

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题名:	Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired pneumonia
作者:	Chiang, T.-Y.;Shyu, L.-Y.;Tsao, Tsao T.-C.Y.;Chien, M.-H.;Tsao, S.-M.;Lee, Y.-T.;Yang, S.-F.
关键词:	community-acquired pneumonia;gene polymorphism;metalloproteinase-9 (MMP-9)
日期:	2012
上传时间:	2017-08-09T03:25:52Z (UTC)
ISSN:	14346621
摘要:	Background: The purpose here was to detect the association among plasma matrix metalloproteinase-9 (MMP-9) concentration, single nucleotide polymorphisms (SNPs) of MMP-9 gene and community-acquired pneumonia (CAP). Methods: The enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were, respectively used to measure the plasma MMP-9 level and its gene polymorphisms. Results: The level of plasma of MMP-9 was elevated in patients with CAP as compared to that of normal controls and decreased significantly after treatment. Plasma MMP-9 concentration was significantly correlated with white blood cell (WBC) and neutrophil counts in patients with CAP. No significant difference was found in the genotypes distribution of MMP-9 SNPs, rs3918242, rs17576 or rs2274756, between patients with CAP and normal controls. Plasma MMP-9 concentration was not associated with MMP-9 polymorphism. When the cut-off level of the plasma MMP-9 concentration was set to be 105.02 ng/mL, the odds ratio of plasma MMP-9 for CAP risk was 9.86 (95 confident interval: 4.2722.75). Plasma MMP-9 level may act as a prediction marker for CAP. Conclusions: Elevated plasma MMP-9 could be a biological marker for the diagnosis and be a new strategy for target therapy of community-acquired pneumonia. © 2012 by Walter de Gruyter Berlin Boston.
URI:	http://dx.doi.org/10.1515/cclm.2011.805 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860435518&doi=10.1515%2fcclm.2011.805&partnerID=40&md5=b2d683d7b897c880817c7f56b3732f75 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18206
關聯:	Clinical Chemistry and Laboratory Medicine 50(3) ,449-454
显示于类别:	[醫學系] 期刊論文

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