Essential oil of Curcuma aromatica induces apoptosis in human non-small-cell lung carcinoma cells

doi:10.1016/j.jff.2016.01.019

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/18200

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题名:	Essential oil of Curcuma aromatica induces apoptosis in human non-small-cell lung carcinoma cells
作者:	Ma, J.-W.;Tsao, Tsao T.C.-Y.;Hsi, Y.-T.;Lin, Y.-C.;Chen, Y.;Chen, Y.;Ho, C.-T.;Kao, J.-Y.;Way, T.-D.
关键词:	Akt/NF-κB;Apoptosis;Curcuma aromatica Salisb;Non-small-cell lung cancer
日期:	2016
上传时间:	2017-08-09T03:25:36Z (UTC)
出版者:	Elsevier Ltd
ISSN:	17564646
摘要:	Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers, and has highly metastatic capacity and poor prognosis. The anti-tumour activity and the corresponding signal pathways of spring Curcuma aromatica Salisb essential oil (CSEO) and autumn C. aromatica essential oil (CAEO) were evaluated. The results demonstrated that CAEO possessed more potent cytotoxicity than CSEO in NSLCL cells. CAEO induced apoptosis through the cleavage and activation of caspases 3, 8, 9, and poly (ADPribose) polymerase (PARP) in NCI-H1299 cells. After treatment with CAEO, pro-apoptosis protein Bax expression increased, and anti-apoptosis proteins Bcl-2 and Bcl-xL expression decreased. In addition, CAEO could promote tumour suppressor protein p53 expression, inhibit the phosphorylation of ERK1/2 and increase the phosphorylation of JNK1/2 and p38. CAEO treatment also inhibited Akt/NF-κB signal pathways in NCI-H1299 cells. In vivo experiments showed that CAEO significantly inhibited the growth of NSCLC in nude mice. Zingiberene (4.80 mg/g), β-sesquiphellandrene (1.88 mg/g) and turmerone (0.98 mg/g) were found in CAEO as potential active compounds. Thus, these results emphasize that the CAEO induced apoptosis and had a potential to become a new functional food ingredient for the prevention and treatment of NSCLC. © 2016.
URI:	http://dx.doi.org/10.1016/j.jff.2016.01.019 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961927205&doi=10.1016%2fj.jff.2016.01.019&partnerID=40&md5=aa0e75d8297dce501a2bf1e12508e258 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18200
關聯:	Journal of Functional Foods 22() ,101-112
显示于类别:	[醫學系] 期刊論文

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