Elevated plasma cathepsin B and cystatin C levels in chronic obstructive pulmonary disease

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/18198

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18198

Title:	Elevated plasma cathepsin B and cystatin C levels in chronic obstructive pulmonary disease
Authors:	Yong, K.-K.;Tsao, S.-M.;Tsao, Tsao T.C.-Y.;Yang, S.-F.
Keywords:	Cathepsin B;Chronic obstructive pulmonary disease;Cystatin C
Date:	2016
Issue Date:	2017-08-09T03:25:31Z (UTC)
Publisher:	E-Century Publishing Corporation
ISSN:	19405901
Abstract:	Background: The aim of this study was to investigate differential changes in plasma levels of cathepsin B and its naturally inhibitory protein cystatin C in chronic obstructive pulmonary disease (COPD) patients during and 2 weeks as well as 8 weeks after acute exacerbation (AE). Materials and methods: Forty six COPD patients, including 44 male and 2 female, were included in this study. Plasma were collected in three different times, i.e., during, and 2 weeks as well as 8 weeks after AE. Plasma cathepsin B and cystatin C levels were measured in 46 adult patients with COPD and 18 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). Results: The plasma levels of cathepsin B were significantly higher in COPD patients at 2 weeks and 8 weeks after AE when compared with those of healthy subjects. The plasma level of cystatin C showed significantly higher than the plasma levels of healthy subjects at time of AE, also 2 weeks and 8 weeks after AE. However, there was no significant difference between the time of AE and 2 or 8 weeks after AE. Conclusions: The persistently significant higher plasma levels of cystatin C in COPD patients not only on AE but also at 2 and 8 weeks after AE than those in healthy subjects might represent a chronic inflammatory status in COPD. Moreover, plasma level of cathepsin B significantly increased at 2 weeks after AE and which returned to be non-significant at 8 weeks after AE in COPD patients. These findings might hint cathepsin B is one of the acute phase reactive protein in AE of COPD. © 2016, E-Century Publishing Corporation. All rights reserved.
URI:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84985992183&partnerID=40&md5=410a129cfd1231e27510550bd811f1cc https://ir.csmu.edu.tw:8080/ir/handle/310902500/18198
Relation:	International Journal of Clinical and Experimental Medicine 9(7) ,14436-14441
Appears in Collections:	[醫學系] 期刊論文

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